スギモト　ケン   Ken Sugimoto   杉本　研    所属   川崎医科大学  医学部 臨床医学　総合老年医学    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Occlusal force predicted cognitive decline among 70- and 80-year-old Japanese: A 3-year prospective cohort study.
掲載誌名	正式名：Journal of prosthodontic research 略　 称：J Prosthodont Res ISSNコード：22124632/18831958
掲載区分	国外
巻・号・頁	64(2),pp.175-181
著者・共著者	Hatta Kodai, Gondo Yasuyuki, Kamide Kei, Masui Yukie, Inagaki Hiroki, Nakagawa Takeshi, Matsuda Ken-Ichi, Inomata Chisato, Takeshita Hajime, Mihara Yusuke, Fukutake Motoyoshi, Kitamura Masahiro, Murakami Shinya, Kabayama Mai, Ishizaki Tatsuro, Arai Yasumichi, Sugimoto Ken, Rakugi Hiromi, Maeda Yoshinobu, Ikebe Kazunori
発行年月	2020/04
概要	PURPOSE:Dementia is a growing health problem for countries with aging populations, but few effective dementia treatments are available. However, there is increasing interest in oral health as a modifiable risk factor in interventions to prevent cognitive decline. This study aimed to investigate the impact of oral health on the decline of cognitive function over 3 years among Japanese people aged 70 and 80 years.METHODS:Participants (n = 860) were community-dwelling older adults who participated in baseline and follow-up surveys (at baseline: 69-71 years n = 423; 79-81 years, n = 437). Registered dentists examined the number of teeth, number of functional teeth, number of periodontal teeth, and occlusal force. The Japanese version of the Montreal Cognitive Assessment was used to evaluate cognitive function. We also evaluated socioeconomic factors, medical history, drinking and smoking habits, physical performance, genetic factors, and C-reactive protein concentration in blood. A generalized estimating equation (GEE) was used to examine how oral health at baseline influenced cognitive decline over 3 years.RESULTS:The GEE showed that the number of teeth (non-standardized coefficient: B = 0.031, p = 0.022) and occlusal force (B = 0.103, p = 0.004) at baseline were associated with cognitive function at follow-up, even after adjusting for other risk factors. Furthermore, maintaining more teeth (B = 0.009, p = 0.004) and a stronger occlusal force (B = 0.020, p = 0.040) buffered cognitive decline.CONCLUSIONS:Number of teeth and occlusal force predict cognitive decline over 3 subsequent years in Japanese older adults aged 70 and 80 years.
DOI	10.1016/j.jpor.2019.07.002
PMID	31685341