Ken Sugimoto
   Department   Kawasaki Medical School  Kawasaki Medical School, Department of General Geriatric Medicine,
   Position   Professor
Article types 原著
Language English
Peer review Peer reviewed
Title Genetic factors associated with elevation of uric acid after treatment with thiazide-like diuretic in patients with essential hypertension.
Journal Formal name：Hypertension research : official journal of the Japanese Society of Hypertension
Abbreviation：Hypertens Res
ISSN code：13484214/09169636
Domestic / ForeginForegin
Volume, Issue, Page 43(3),pp.220-226
Author and coauthor Ohta Yuko, Kamide Kei, Hanada Hironori, Morimoto Shigeto, Nakahashi Takeshi, Takiuchi Shin, Ishimitsu Toshihiko, Tsuchihashi Takuya, Soma Masayoshi, Tomohiro Katsuya T, Sugimoto Ken, Rakugi Hiromi, Oukura Takafumi, Higaki Jitsuo, Matsuura Hideo, Shinagawa Tatsuo, Miwa Yosikazu, Sasaguri Toshiyuki, Igase Michiya, Miki Tetsuro, Takeda Kazuo, Higashiura Katsuhiro, Shimamoto Kazuaki, Katabuchi Ritsuko, Ueno Michio, Hosomi Naonaga, Kato Johji, Komai Norio, Kojima Shunichi, Sase Kazuhiro, Iwashima Yoshio, Yoshihara Fumiki, Horio Takeshi, Nakamura Satoko, Nakahama Hajime, Miyata Toshiyuki, Kawano Yuhei
Publication date 2020/03
Summary We investigated changes in blood pressure (BP) and metabolic adverse effects, especially elevation of uric acid (UA), after treatment with a thiazide-like diuretic (TD) in patients with essential hypertension. Furthermore, the role of genetic factors in the elevation of UA by TD was assessed by a 500 K SNP DNA microarray. The subjects included 126 hypertensive patients (57 women and 69 men, mean age 59 ± 12 years) who registered for the GEANE (Gene Evaluation for ANtihypertensive Effects) study. After one month of the nontreatment period, TD, indapamide, angiotensin II receptor antagonist valsartan, and Ca channel blocker amlodipine were administered to all patients for 3 months each in a randomized crossover manner. BP, renal function, serum UA level, and electrolytes were measured at baseline and at the end of each treatment period. Single nucleotide polymorphisms (SNPs) associated with UA elevation after treatment with indapamide were investigated by a genome-wide association study (GWAS). Indapamide significantly decreased both office and home BP levels. Treatment with indapamide also significantly reduced the estimated glomerular filtration rate and serum potassium and increased serum UA. Patients whose UA level increased more than 1 mg/dl showed significantly higher baseline office SBP and plasma glucose and showed greater decline in renal function compared with those who showed less UA increase (<1 mg/dl). Some SNPs strongly associated with an increase in UA after treatment with indapamide were identified. This study is the first report on SNPs associated with UA elevation after TD treatment. This information may be useful for the prevention of adverse effects after treatment with TD.
DOI 10.1038/s41440-019-0356-x
PMID 31748705