杉本 研
   Department     ,
   Position  
Article types 原著
Language English
Peer review Non peer reviewed
Presence of invitation Invited paper
Title Modified forelimb grip strength test detects aging-associated physiological decline in skeletal muscle function in male mice.
Journal Formal name:Scientific reports
Abbreviation:Sci Rep
ISSN code:20452322/20452322
Domestic / ForeginForegin
Volume, Issue, Page 7,42323頁
Author and coauthor Takeshita Hikari, Yamamoto Koichi, Nozato Satoko, Inagaki Tadakatsu, Tsuchimochi Hirotsugu, Shirai Mikiyasu, Yamamoto Ryohei, Imaizumi Yuki, Hongyo Kazuhiro, Yokoyama Serina, Takeda Masao, Oguro Ryosuke, Takami Yoichi, Itoh Norihisa, Takeya Yasushi, Sugimoto Ken, Fukada So-Ichiro, Rakugi Hiromi
Publication date 2017/02
Summary The conventional forelimb grip strength test is a widely used method to assess skeletal muscle function in rodents; in this study, we modified this method to improve its variability and consistency. The modified test had lower variability among trials and days than the conventional test in young C57BL6 mice, especially by improving the variabilities in male. The modified test was more sensitive than the conventional test to detect a difference in motor function between female and male mice, or between young and old male mice. When the modified test was performed on male mice during the aging process, reduction of grip strength manifested between 18 and 24 months of age at the group level and at the individual level. The modified test was similar to the conventional test in detecting skeletal muscle dysfunction in young male dystrophic mice. Thus, the modified forelimb grip strength test, with its improved validity and reliability may be an ideal substitute for the conventional method.
DOI 10.1038/srep42323
PMID 28176863