Ken Sugimoto    Department   Kawasaki Medical School  Kawasaki Medical School, Department of General Geriatric Medicine,    Position   Professor
Article types	原著
Language	English
Peer review	Peer reviewed
Title	Differences in the association between high blood pressure and cognitive functioning among the general Japanese population aged 70 and 80 years: The SONIC study.
Journal	Formal name：Hypertension research : official journal of the Japanese Society of Hypertension Abbreviation：Hypertens Res ISSN code：13484214/09169636
Domestic / Foregin	Foregin
Volume, Issue, Page	39(7),pp.557-563
Author and coauthor	Ryuno Hirochika, Kamide Kei, Gondo Yasuyuki, Nakama Chikako, Oguro Ryosuke, Kabayama Mai, Kawai Tatsuo, Kusunoki Hiroshi, Yokoyama Serina, Imaizumi Yuki, Takeya Miyuki, Yamamoto Hiroko, Takeda Masao, Takami Yoichi, Itoh Norihisa, Yamamoto Koichi, Takeya Yasushi, Sugimoto Ken, Nakagawa Takeshi, Ikebe Kazunori, Inagaki Hiroki, Masui Yukie, Ishizaki Tatsuro, Takayama Michiyo, Arai Yasumichi, Takahashi Ryutaro, Rakugi Hiromi
Publication date	2016/07
Summary	High blood pressure in middle age (up to 64 years) has been proposed as a predictive indicator of dementia. However, the association between hypertension and the cognitive functioning is controversial in older age groups. The aim of this study was to investigate this association in 70-80-year-old participants in the Japanese study of Septuagenarians, Octogenarians and Nonagenarians Investigation with Centenarians (SONIC). Participants aged 70 (±1) and 80 (±1) years (n=1000 and 973, respectively) were randomly recruited from the general population in Japan. Cognitive functioning was measured by the Montreal Cognitive Assessment. Blood pressure and other medical and social variables were analyzed by multiple regression analyses. High systolic blood pressure (SBP) was significantly correlated with a reduced cognitive functioning only in participants aged 70 years. Additionally, this correlation became more marked in participants with uncontrolled blood pressure at age 70 years. In contrast, SBP was not significantly correlated with the cognitive functioning at age 80 years. Nutritional status indicators such as serum albumin and frequency of going outdoors were significantly associated with cognitive functioning at age 80 years. Our findings indicate that high SBP has a significant role in cognitive functioning at age 70 years; however, blood pressure is less important as a risk factor for cognitive decline at age 80 years.
DOI	10.1038/hr.2016.25
PMID	27009579