杉本 研
   Department     ,
   Position  
Article types 原著
Language English
Peer review Peer reviewed
Title Association Analysis of FOXO3 Longevity Variants With Blood Pressure and Essential Hypertension.
Journal Formal name:American journal of hypertension
Abbreviation:Am J Hypertens
ISSN code:19417225/08957061
Domestic / ForeginForegin
Volume, Issue, Page 29(11),1292-1300頁
Author and coauthor Morris Brian J, Chen Randi, Donlon Timothy A, Evans Daniel S, Tranah Gregory J, Parimi Neeta, Ehret Georg B, Newton-Cheh Christopher, Seto Todd, Willcox D Craig, Masaki Kamal H, Kamide Kei, Ryuno Hirochika, Oguro Ryosuke, Nakama Chikako, Kabayama Mai, Yamamoto Koichi, Sugimoto Ken, Ikebe Kazunori, Masui Yukie, Arai Yasumichi, Ishizaki Tatsuro, Gondo Yasuyuki, Rakugi Hiromi, Willcox Bradley J
Publication date 2016/11
Summary BACKGROUND:The minor alleles of 3 FOXO3 single nucleotide polymorphisms (SNPs)- rs2802292 , rs2253310 , and rs2802288 -are associated with human longevity. The aim of the present study was to test these SNPs for association with blood pressure (BP) and essential hypertension (EHT).METHODS:In a primary study involving Americans of Japanese ancestry drawn from the Family Blood Pressure Program II we genotyped 411 female and 432 male subjects aged 40-79 years and tested for statistical association by contingency table analysis and generalized linear models that included logistic regression adjusting for sibling correlation in the data set. Replication of rs2802292 with EHT was attempted in Japanese SONIC study subjects and of each SNP in a meta-analysis of genome-wide association studies of BP in individuals of European ancestry.RESULTS:In Americans of Japanese ancestry, women homozygous for the longevity-associated (minor) allele of each FOXO3 SNP had 6mm Hg lower systolic BP and 3mm Hg lower diastolic BP compared with major allele homozygotes (Bonferroni corrected P < 0.05 and >0.05, respectively). Frequencies of minor allele homozygotes were 3.3-3.9% in women with EHT compared with 9.5-9.6% in normotensive women ( P = 0.03-0.04; haplotype analysis P = 0.0002). No association with BP or EHT was evident in males. An association with EHT was seen for the minor allele of rs2802292 in the Japanese SONIC cohort ( P = 0.03), while in European subjects the minor allele of each SNP was associated with higher systolic and diastolic BP.CONCLUSION:Longevity-associated FOXO3 variants may be associated with lower BP and EHT in Japanese women.
DOI 10.1093/ajh/hpv171
PMID 26476085