Ken Sugimoto    Department   Kawasaki Medical School  Kawasaki Medical School, Department of General Geriatric Medicine,    Position   Professor
Article types	原著
Language	English
Peer review	Peer reviewed
Title	Disease-associated polymorphisms in 9p21 are not associated with extreme longevity.
Journal	Formal name：Geriatrics & gerontology international Abbreviation：Geriatr Gerontol Int ISSN code：14470594/14470594
Domestic / Foregin	Foregin
Volume, Issue, Page	15(6),pp.797-803
Author and coauthor	Congrains Ada, Kamide Kei, Hirose Nobuyoshi, Arai Yasumichi, Oguro Ryousuke, Nakama Chikako, Imaizumi Yuki, Kawai Tatsuo, Kusunoki Hiroshi, Yamamoto Hiroko, Onishi-Takeya Miyuki, Takeya Yasushi, Yamamoto Koichi, Sugimoto Ken, Akasaka Hiroshi, Saitoh Shigeyuki, Miura Tetsuji, Awata Nobuhisa, Kato Norihiro, Katsuya Tomohiro, Ikebe Kazunori, Gondo Yasuyuki, Rakugi Hiromi
Publication date	2015/06
Summary	AIM:The 9p21 region has been pointed out by the genome-wide association studies as a hot spot for disease-associated variants. Most of the diseases linked with the locus are aging-related conditions, such us cardiovascular disease, diabetes and cancer. Centenarians are known to present a reduced risk and delayed onset for these conditions. Here, we aimed to assess if the 9p21 variants contribute to this protection by possibly altering basic aging mechanisms.METHODS:We genotyped 15 tag single-nucleotide polymorphisms (SNP) along the CDKN2A/B/ANRIL locus in 1505 individuals. The participants were divided in three groups: centenarians, septuagenarians and young controls. Centenarians were 593 participants (age range 100-116 years, mean 105.9 years), septuagenarians were 434 volunteers aged between 69 and 71 years (mean 70.1 ± 0.9 years) and the 478 young controls were under the age of 50 years (range 14-50 years, mean 41.8 years). We genotyped the SNP rs1333049 in an additional sample of 231 coronary artery disease patients to confirm the 9p21 association.RESULTS:The leading coronary artery disease-associated SNP rs1333049 was associated with coronary artery disease; however, none of the 9p21 SNP evaluated in the present study were associated with extreme longevity.CONCLUSIONS:Our findings suggest that the 9p21 disease-associated polymorphisms do not contribute to the life-long protection from cardiovascular and other age-related diseases observed in centenarians. It is likely that this protection is mediated by mechanisms different from the ones underlying the 9p21 association.
DOI	10.1111/ggi.12346
PMID	25257646