スギモト　ケン   Ken Sugimoto   杉本　研    所属   川崎医科大学  医学部 臨床医学　総合老年医学    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	[Transdisciplinary Approach for Sarcopenia. The application of life style diseases-animal models to the research for sarcopenia].
掲載誌名	正式名：Clinical calcium 略　 称：Clin Calcium ISSNコード：09175857/09175857
掲載区分	国外
巻・号・頁	24(10),pp.1479-1486
著者・共著者	Sugimoto Ken, Rakugi Hiromi
発行年月	2014/10
概要	Sarcopenia can be developed based on loss of skeletal muscle mass induced by various age-related factors, and suitable animal models must be needed to elucidate the mechanism of sarcopenia. Since loss of skeletal muscle mass is observed earlier in the elderly with lifestyle-related diseases than in the health elderly, animal models for lifestyle-related diseases can be applicable to the research for sarcopenia. Several reports using animal models for diabetes or specific diet-fed animals show that insulin resistance, hyperglycemia, increase of glucocorticoids, low-grade inflammation and accumulation of advanced glycation end products (AGEs) can accelerate loss of skeletal muscle mass. Thus, the application of these animal models to further investigations on prevention or intervention for sarcopenia will be widely expected.
DOI	CliCa141014791486
PMID	25266093