杉本 研
   Department     ,
   Position  
Article types 原著
Language English
Peer review Peer reviewed
Title Relationship between renal hemodynamic status and aging in patients without diabetes evaluated by renal Doppler ultrasonography.
Journal Formal name:Clinical and experimental nephrology
Abbreviation:Clin Exp Nephrol
ISSN code:14377799/13421751
Domestic / ForeginForegin
Volume, Issue, Page 16(5),786-791頁
Author and coauthor Kawai Tatsuo, Kamide Kei, Onishi Miyuki, Hongyo Kazuhiro, Yamamoto-Hanasaki Hiroko, Oguro Ryosuke, Maekawa Yoshihiro, Yamamoto Koichi, Takeya Yasushi, Sugimoto Ken, Ohishi Mitsuru, Rakugi Hiromi
Publication date 2012/10
Summary BACKGROUND:Aging is well known as one of the major causes of a reduced glomerular filtration rate (GFR). The resistive index (RI) measured by renal Doppler ultrasonography (RDU) is thought to be a good indicator of renal vascular resistance induced by arteriosclerosis. In this study, we investigated whether RI could be used to evaluate the pathogenesis of renal damage or the mechanisms of reduction of renal function by aging.METHODS:We investigated the correlation between RI and multiple clinical parameters and the influence of aging on the renal hemodynamic status of 194 in-patients (mean age 66.2 years) who underwent RDU at our hospital between February 2009 and July 2010.RESULTS:RI was significantly correlated with the age, estimated GFR (eGFR), diastolic blood pressure, pulse pressure, and degree of albuminuria. Subjects aged ≥75 years showed a significantly higher correlation coefficient between eGFR and RI. RI showed a stronger correlation with age in subjects aged ≥75 years compared to eGFR.CONCLUSION:The present study showed that renal vascular resistance and intra-renal arteriosclerosis had a greater impact on renal function in older than younger subjects, reflecting the possible mechanisms of renal function reduction due to aging.
DOI 10.1007/s10157-012-0627-1
PMID 22492010