Ken Sugimoto
Department Kawasaki Medical School Kawasaki Medical School, Department of General Geriatric Medicine, Position Professor |
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Article types | 原著 |
Language | English |
Peer review | Peer reviewed |
Title | Identification of evidence suggestive of an association with peripheral arterial disease at the OSBPL10 locus by genome-wide investigation in the Japanese population. |
Journal | Formal name:Journal of atherosclerosis and thrombosis Abbreviation:J Atheroscler Thromb ISSN code:18803873/13403478 |
Domestic / Foregin | Foregin |
Volume, Issue, Page | 17(10),pp.1054-1062 |
Author and coauthor | Koriyama Hiroshi, Nakagami Hironori, Katsuya Tomohiro, Sugimoto Ken, Yamashita Hidetoshi, Takami Yoichi, Maeda Shiro, Kubo Michiaki, Takahashi Atsushi, Nakamura Yusuke, Ogihara Toshio, Rakugi Hiromi, Kaneda Yasufumi, Morishita Ryuichi |
Publication date | 2010/10 |
Summary | AIM:Peripheral arterial disease (PAD) is a common cause of cardiovascular morbidity and an independent predictor of cardiovascular mortality. However, little is known about the genetic basis of PAD. To elucidate this, we performed a two-staged genome-wide association study in Japanese individuals.METHODS:We initially tested 222,285 single-nucleotide polymorphisms (SNPs). After the first screening in a panel of 195 PAD cases and 1,358 controls, 2,696 SNPs (1.2%) were further genotyped in the second screening using another panel of 699 PAD cases and 1540 controls. In both screenings, controls were subjects affected with some diseases other than PAD.RESULTS:When analyzed in the combined panel, the strongest signal of PAD association was observed at rs1902341 in the intron of OSBPL10 (p=4.7E-7 for trend test; OR=1.31, 95% CI 1.18-1.46). Also, PAD was modestly associated at several other loci such as rs2554503 in CSMD1 (p=5.7E-5; OR=1.32, 95% CI 1.15-1.51) or rs235243 in VSP13D (p=0.04; OR=1.18, 95% CI 1.01-1.37).CONCLUSION:Our genome-wide exploration identified suggestive evidence of PAD association at the OSBPL10 locus. Because the association has not reached a genome-wide significant level, further replication study is warranted for verification in the Japanese population. |
DOI | 10.5551/jat.4291 |
PMID | 20610895 |