杉本 研
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   Position  
Article types 原著
Language English
Peer review Peer reviewed
Title Association of gene polymorphism of the fat-mass and obesity-associated gene with insulin resistance in Japanese.
Journal Formal name:Hypertension research : official journal of the Japanese Society of Hypertension
Abbreviation:Hypertens Res
ISSN code:13484214/09169636
Domestic / ForeginForegin
Volume, Issue, Page 33(3),214-218頁
Author and coauthor Shimaoka Izumi, Kamide Kei, Ohishi Mitsuru, Katsuya Tomohiro, Akasaka Hiroshi, Saitoh Shigeyuki, Sugimoto Ken, Oguro Ryousuke, Congrains Ada, Fujisawa Tomomi, Shimamoto Kazuaki, Ogihara Toshio, Rakugi Hiromi
Publication date 2010/03
Summary It was reported that gene polymorphisms in the fat-mass and obesity-associated gene (FTO) were associated with obesity and diabetes in several genome-wide association studies. A recent report indicated that FTO-knockout mice exhibited phenotypes of skinny body shape and normal metabolic profiles. Thus, FTO could be important in metabolic disorders. The aim of this study was to clarify the role of single nucleotide polymorphisms (SNPs) in FTO in metabolic disorders such as hypertension, obesity, diabetes, dyslipidemia, insulin resistance and metabolic syndrome in the Japanese general population using data from a cohort study in Hokkaido, namely the Tanno-Sobetsu study. Written informed consent for the genetic analysis was obtained from each subject participating in the study. A total of 1514 subjects were genotyped by TaqMan PCR methods for three SNPs, rs9939609, rs1121980 and rs1558902, in FTO. Association analyses between the SNPs and metabolic parameters were performed. Although two SNPs, rs9939609 and rs1558902, were not significantly associated with hypertension, obesity, metabolic syndrome or any metabolic parameters, additive and recessive models of rs1121980 were strongly associated with plasma immunoreactive insulin (IRI) level and homeostasis model assessment insulin resistance (HOMA-IR), even after adjusting for confounding factors such as age, gender and body mass index. A haplotype of three SNPs was also significantly associated with IRI and HOMA-IR. One SNP, rs1121980, and a haplotype of three SNPs in FTO that contains this SNP, might be important in the progression of insulin resistance in Japanese subjects.
DOI 10.1038/hr.2009.215
PMID 20075932