杉本 研
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Article types 原著
Language English
Peer review Peer reviewed
Title Accumulation of common polymorphisms is associated with development of hypertension: a 12-year follow-up from the Ohasama study.
Journal Formal name:Hypertension research : official journal of the Japanese Society of Hypertension
Abbreviation:Hypertens Res
ISSN code:13484214/09169636
Domestic / ForeginForegin
Volume, Issue, Page 33(2),129-134頁
Author and coauthor Watanabe Yumiko, Metoki Hirohito, Ohkubo Takayoshi, Katsuya Tomohiro, Tabara Yasuharu, Kikuya Masahiro, Hirose Takuo, Sugimoto Ken, Asayama Kei, Inoue Ryusuke, Hara Azusa, Obara Taku, Nakura Jun, Kohara Katsuhiko, Totsune Kazuhito, Ogihara Toshio, Rakugi Hiromi, Miki Tetsuro, Imai Yutaka
Publication date 2010/02
Summary Hypertension is a complex multi-factorial and polygenic disorder. Nevertheless, most studies have focused on single-gene effects. Furthermore, a majority of these studies have been cross-sectional and diagnosed hypertension using conventional blood pressure (BP) measurements, which are known to be subject to biases, including the so-called white-coat effect. Thus, we performed a longitudinal association study to clarify the effects of polymorphism accumulation on the development of hypertension that is defined on the basis of self-measured BP at home (home BP). In 403 Japanese aged 40-79 years with home normotension (home BP <135/85 mm Hg, and not treated with antihypertensive medication at baseline), we examined the associations of 51 single-nucleotide polymorphisms (SNPs) classically nominated or reported to be associated with hypertension in the Japanese Millennium Genome Project for Hypertension with a 12-year risk of progression to home hypertension (home BP >or=135/85 mm Hg, or start of antihypertensive medication). Out of 51 SNPs, four significantly and independently predicted the risk of progression of home hypertension, even after adjustment for possible confounding factors, including baseline home BP value. These were rs3767489 near the regulator of G-protein signaling 2 (RGS2), rs4961 in adducin 1 (ADD1), rs2236957 in the calcium channel, voltage-dependent, alpha-2/delta-subunit 2 (CACNA2D2) and rs769214 in catalase (CAT). Accumulation of these SNPs significantly improved the predictive values for the development of home hypertension. In conclusion, this longitudinal study, which was based on home BP measurement, showed that accumulation of common polymorphisms reliably predicted the risk of future hypertension in the Japanese general population.
DOI 10.1038/hr.2009.193
PMID 19927152