杉本 研
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Article types 原著
Language English
Peer review Peer reviewed
Title A promoter polymorphism of lamin A/C gene is an independent genetic predisposition to arterial stiffness in a Japanese general population (the Tanno and Sobetsu study).
Journal Formal name:Journal of atherosclerosis and thrombosis
Abbreviation:J Atheroscler Thromb
ISSN code:18803873/13403478
Domestic / ForeginForegin
Volume, Issue, Page 16(4),404-409頁
Author and coauthor Akasaka Hiroshi, Katsuya Tomohiro, Saitoh Shigeyuki, Sugimoto Ken, Ohnishi Hirofumi, Congrains Ada, Ohnishi Miyuki, Ohishi Mitsuru, Rakugi Hiromi, Ogihara Toshio, Shimamoto Kazuaki
Publication date 2009/08
Summary AIM:We examined the hypothesis that there is a positive, independent association between polymorphisms of lamin A/C gene (LMNA) and arterial stiffness in Japanese.METHODS:The subjects were 261 men (mean age, 64.4+/-0.7 years) selected from inhabitants of the towns of Tanno and Sobetsu in a rural area of Japan who underwent medical check-ups. We conducted clinical examinations, including measurement of bilateral brachial-ankle pulse wave velocity (baPWV) as a marker of arterial stiffness, and genetic analysis. Subjects with atrial fibrillation, subjects with ankle-brachial index <0.9, and subjects taking any medication were excluded. We selected two single nucleotide polymorphisms (SNPs) as markers of LMNA, 1908C/T in exon 10 and -1030C/T in the promoter region, which we have recently identified. All genotypes were clearly determined by the TaqMan PCR method.RESULTS:Genotype frequencies of the two polymorphisms satisfied the Hardy-Weinberg equilibrium. The baPWV of -1030C/T polymorphism was significantly greater in subjects with CC genotype than in subjects with CT+TT genotype (1,652+/-22.1 cm/s vs. 1,552+/-43.0 cm/s, p=0.039); however, no significant difference was found for 1908C/T polymorphism. The baPWV was found to be significantly associated with age, body height, systolic blood pressure, and smoking habit; therefore, we next performed multiple regression analysis including these parameters, and found an independent, significant association between baPWV and -1030C/T polymorphism.CONCLUSION:Promoter -1030C/T polymorphism of LMNA is a possible genetic predisposition to arterial stiffness in the Japanese population.
DOI 10.5551/jat.no1271
PMID 19672032