Ken Sugimoto
   Department   Kawasaki Medical School  Kawasaki Medical School, Department of General Geriatric Medicine,
   Position   Professor
Article types 原著
Language English
Peer review Peer reviewed
Title Hypoadiponectinemia is an independent risk factor for hypertension.
Journal Formal name：Hypertension (Dallas, Tex. : 1979)
Abbreviation：Hypertension
ISSN code：15244563/0194911X
Domestic / ForeginForegin
Volume, Issue, Page 43(6),pp.1318-1323
Author and coauthor Iwashima Yoshio, Katsuya Tomohiro, Ishikawa Kazuhiko, Ouchi Noriyuki, Ohishi Mitsuru, Sugimoto Ken, Fu Yuxiao, Motone Masaharu, Yamamoto Kouichi, Matsuo Akiko, Ohashi Koji, Kihara Shinji, Funahashi Tohru, Rakugi Hiromi, Matsuzawa Yuji, Ogihara Toshio
Publication date 2004/06
Summary Adiponectin is one of the key molecules in the metabolic syndrome, and its concentration is decreased in obesity, type-2 diabetes, and coronary artery disease. Genetic investigation has revealed that 2 polymorphisms (I164T and G276T) are related to adiponectin concentration and diabetes. To examine whether adiponectin affects hypertension genetically or biologically, we performed a case-control study. A total of 446 diagnosed cases of hypertension (HT) in men and 312 normotensive (NT) men were enrolled in this study. Plasma adiponectin concentration was measured using an enzyme-linked immunosorbent assay system. Single nucleotide polymorphisms were determined by TaqMan polymerase chain reaction method. After adjustment for confounding factors, adiponectin concentration was significantly lower in HT (HT: 5.2+/-0.2 microg/mL; NT: 6.1+/-0.2 microg/mL; P<0.001). Furthermore, multiple regression analysis indicated that hypoadiponectinemia was an independent risk factor for hypertension (P<0.001). Blood pressure was inversely associated with adiponectin concentration in normotensives regardless of insulin resistance. In subjects carrying the TC genotype of the I164T polymorphism, adiponectin concentration was significantly lower (TC: 2.6+/-0.9 microg/mL; TT: 5.5+/-0.1 microg/mL; P<0.01), and most of them had hypertension. In contrast, the G276T polymorphism was not associated with adiponectin concentration or hypertension. In conclusion, hypoadiponectinemia is a marker for predisposition to hypertension in men.
DOI 10.1161/01.HYP.0000129281.03801.4b
PMID 15123570