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Ken Sugimoto
Department Kawasaki Medical School Kawasaki Medical School, Department of General Geriatric Medicine, Position Professor |
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| Article types | 原著 |
| Language | English |
| Peer review | Peer reviewed |
| Title | Lack of correlation between Mbo I restriction fragment length polymorphism of renin gene and essential hypertension in Japanese. |
| Journal | Formal name：Hypertension research : official journal of the Japanese Society of Hypertension Abbreviation：Hypertens Res ISSN code：09169636/09169636 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 24(3),pp.295-298 |
| Author and coauthor | Fu Y, Katsuya T, Asai T, Fukuda M, Inamoto N, Iwashima Y, Sugimoto K, Rakugi H, Higaki J, Ogihara T |
| Publication date | 2001/05 |
| Summary | Predisposition to essential hypertension is associated with gene polymorphisms of the renin angiotensin system (RAS). Gene polymorphisms of the angiotensinogen and angiotensin converting enzyme genes are known to be risk factors for hypertension, while few studies concerning the renin gene polymorphism have been published. In the present investigation, we carried out a case control study using a Japanese population to examine the genetic influence of the renin gene on the predisposition to hypertension. Patients (n=235) recruited from outpatients at Osaka University Hospital and diagnosed with essential hypertension or receiving long-term antihypertensive medication participated in the study. Normotensive control subjects (n=510) without a history of hypertension and without diabetes mellitus were recruited from the same population, and were sex-matched with experimental subjects. A polymorphism in intron 9 of the human renin gene was determined as the Mbo I restriction fragment length polymorphism (Mbo I-RFLP). There was no significant association between Mbo I-RFLP of the renin gene and predisposition to essential hypertension in Japanese (p>0.05, chi2=2.1). These results suggest that the Mbo I (+) allele of the renin gene does not increase the risk for hypertension in Japanese. |
| DOI | 10.1291/hypres.24.295 |
| PMID | 11409653 |