Yuta Ishizuka
   Department   Kawasaki Medical School  Kawasaki Medical School, Department of Pathophysiology and Metabolism,
   Position   Assistant Professor
Article types 原著
Language English
Peer review Peer reviewed
Title The anthraquinone derivative emodin attenuates methamphetamine-induced hyperlocomotion and startle response in rats.
Journal Formal name：Pharmacology, biochemistry, and behavior
Abbreviation：Pharmacol Biochem Behav
ISSN code：18735177/00913057
Domestic / ForeginForegin
Publisher ELSEVIER
Volume, Issue, Page 97(2),pp.392-8
Author and coauthor Makoto Mizuno, Hiroki Kawamura, Yuta Ishizuka, Hidekazu Sotoyama, Hiroyuki Nawa
Publication date 2010/12
Summary Abnormal signaling mediated by epidermal growth factor (EGF) or its receptor (ErbB) is implicated in the neuropathology of schizophrenia. Previously, we found that the anthraquinone derivative emodin (3-methyl-1,6,8-trihydroxyanthraquinone) inhibits ErbB1 signaling and ameliorates behavioral deficits of the schizophrenia animal model established by EGF challenge. In the present study, we assessed acute and subchronic effects of its administration on methamphetamine-triggered behavioral hyperactivation in rats. Prior subchronic administration of emodin (50mg/kg/day, 5days, p.o.) suppressed both higher acoustic startle responses and hyperlocomotion induced by acute methamphetamine challenge. In parallel, emodin also attenuated methamphetamine-induced increases in dopamine and its metabolites and decreases in serotonin and its metabolites. Emodin administered alone also had an effect on stereotypic movement but no influence on horizontal or vertical locomotor activity. In contrast to pre-treatment, post-treatment with emodin had no effect on behavioral sensitization to methamphetamine. Administration of emodin in parallel to or following repeated methamphetamine challenge failed to affect hyperlocomotion induced by methamphetamine re-challenges. These findings suggest that emodin has unique pharmacological activity, which interferes with acute methamphetamine signaling and behavior.
DOI 10.1016/j.pbb.2010.09.009
PMID 20863847