Sotatsu Tonomura    Department   Kawasaki Medical School  Kawasaki Medical School, Department of Anatomy,    Position   Instructor
Article types	原著
Language	English
Peer review	Peer reviewed
Title	How many hair follicles are innervated by one afferent axon? A confocal microscopic analysis of palisade endings in the auricular skin of thy1-YFP transgenic mouse
Journal	Formal name：Proc Jpn Acad Ser B Phys Biol Sci
Domestic / Foregin	Domestic
Volume, Issue, Page	88(10),pp.583-95
Author and coauthor	Suzuki, M. Ebara, S. Koike, T. Tonomura, S. Kumamoto, K.
Publication date	2012
Summary	Hairs are known as a sensory apparatus for touch. Their follicles are innervated predominantly by palisade endings composed of longitudinal and circumferential lanceolate endings. However, little is known as to how their original primary neurons make up a part of the ending. In this study, innervation of the palisade endings was investigated in the auricular skin of thy1-YFP transgenic mouse. Major observations were 1) Only a small portion of PGP9.5-immunopositive axons showed YFP-positivity, 2) All of thy1-YFP-positive sensory axons were thick and myelinated, 3) Individual thy1-YFP-positive trunk axons innervated 4-54 hair follicles, 4) Most palisade endings had a gap of lanceolate ending arrangement, 5) PGP9.5-immunopositive 10-32 longitudinal lanceolate endings were closely arranged. Only a part of them were thy1-YFP-positive axons that originated from 1-3 afferents, and 6) Single nerve bundles of the dermal nerve network included both bidirectional afferents. Palisade endings innervated by multiple sensory neurons might be highly sensitive to hair movement.
DOI	10.2183/pjab.88.583
Document No.	23229751