Nagio Takigawa
Department Kawasaki Medical School Kawasaki Medical School, Department of General Internal Medicine 4, Position Professor |
|
Article types | 症例報告 |
Language | English |
Peer review | Peer reviewed |
Title | Disappearance of an activated EGFR mutation after treatment with EGFR tyrosine kinase inhibitors |
Journal | Formal name:Lung cancer Abbreviation:Lung cancer |
Volume, Issue, Page | 78(1),pp.121-124 |
Author and coauthor | Honda Yoshihiro, Takigawa Nagio, Fushimi Soichiro, Ochi Nobuaki, Kubo Toshio, Ozaki Saeko, Tanimoto Mitsune, Kiura Katsuyuki |
Authorship | 2nd author,Corresponding author |
Publication date | 2012/10 |
Summary | A 34-year-old Japanese woman presented with left supraclavicular lymph node swelling. Computed tomography scans revealed a mass on the left lower lobe, pulmonary nodules, and pleural effusion. A lymph node biopsy revealed large-cell carcinoma with an epidermal growth factor receptor (EGFR) deletion mutation, L747-T751 in exon 19. Although malignant pleural effusions carried the same EGFR mutation, progressive pleural effusions after treatment with chemotherapy, gefitinib, and erlotinib did not show any EGFR mutation. A cell line established from the pleural effusion 3 days before the patient expired also did not harbor the EGFR mutation. Histological sections of the lymph node of the patient were similar to those of the xenograft tumor of the cell line. There may be genetic heterogeneity in EGFR mutant tumors. |
DOI | 10.1016/j.lungcan.2012.07.003 |
Document No. | 22835516 |