タキガワ　ナギオ   Nagio Takigawa   瀧川　奈義夫    所属   川崎医科大学  医学部 臨床医学　総合内科学４    職種   教授
論文種別	症例報告
言語種別	英語
査読の有無	査読あり
表題	Disappearance of an activated EGFR mutation after treatment with EGFR tyrosine kinase inhibitors
掲載誌名	正式名：Lung cancer 略　 称：Lung cancer
巻・号・頁	78(1),pp.121-124
著者・共著者	Honda Yoshihiro, Takigawa Nagio, Fushimi Soichiro, Ochi Nobuaki, Kubo Toshio, Ozaki Saeko, Tanimoto Mitsune, Kiura Katsuyuki
担当区分	2nd著者,責任著者
発行年月	2012/10
概要	A 34-year-old Japanese woman presented with left supraclavicular lymph node swelling. Computed tomography scans revealed a mass on the left lower lobe, pulmonary nodules, and pleural effusion. A lymph node biopsy revealed large-cell carcinoma with an epidermal growth factor receptor (EGFR) deletion mutation, L747-T751 in exon 19. Although malignant pleural effusions carried the same EGFR mutation, progressive pleural effusions after treatment with chemotherapy, gefitinib, and erlotinib did not show any EGFR mutation. A cell line established from the pleural effusion 3 days before the patient expired also did not harbor the EGFR mutation. Histological sections of the lymph node of the patient were similar to those of the xenograft tumor of the cell line. There may be genetic heterogeneity in EGFR mutant tumors.
DOI	10.1016/j.lungcan.2012.07.003
文献番号	22835516