オチ　ノブアキ   Nobuaki Ochi   越智　宣昭    所属   川崎医科大学  医学部 臨床医学　総合内科学４    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Treatment-related death in patients with small-cell lung cancer in phase III trials over the last two decades
掲載誌名	正式名：PLoS ONE 略　 称：PLoS ONE
巻・号・頁	7(8),pp.e42798
著者・共著者	Ochi Nobuaki, Hotta Katsuyuki, Takigawa Nagio, Oze Isao, Fujiwara Yoshiro, Ichihara Eiki, Hisamoto Akiko, Tabata Masahiro, Tanimoto Mitsune, Kiura Katsuyuki
担当区分	筆頭著者
発行年月	2012/08
概要	INTRODUCTION: Treatment-related death (TRD) remains a serious problem in small-cell lung cancer (SCLC), despite recent improvements in supportive care. However, few studies have formally assessed time trends in the proportion of TRD over the past two decades. The aim of this study was to determine the frequency and pattern of TRD over time. METHODS: We examined phase 3 trials conducted between 1990 and 2010 to address the role of systemic treatment for SCLC. The time trend was assessed using linear regression analysis. RESULTS: In total, 97 trials including nearly 25,000 enrolled patients were analyzed. The overall TRD proportion was 2.95%. Regarding the time trend, while it was not statistically significant, it tended to decrease, with a 0.138% decrease per year and 2.76% decrease per two decades. The most common cause of death was febrile neutropenia without any significant time trend in its incidence over the years examined (p = 0.139). However, deaths due to febrile neutropenia as well as all causes in patients treated with non-platinum chemotherapy increased significantly (p = 0.033). CONCLUSIONS: The overall TRD rate has been low, but not negligible, in phase III trials for SCLC over the past two decades.
DOI	10.1371/journal.pone.0042798