Shigeki Ono    Department   Kawasaki Medical School  Kawasaki Medical School, Department of Neurosurgery 2,    Position   Professor
Article types	原著
Language	English
Peer review	Peer reviewed
Title	Vasospasm in monkeys resolves because of loss of and encasement of subarachnoid blood clot.
Journal	Formal name：Stroke; a journal of cerebral circulation Abbreviation：Stroke ISSN code：00392499/15244628
Volume, Issue, Page	32(8),pp.1868-1874
Author and coauthor	Zhang ZD, Yamini B, Komuro T, Ono S, Johns L, Marton LS, Weir B, Macdonald RL.
Publication date	2001/08
Summary	BACKGROUND AND PURPOSE: We studied in monkeys why vasospasm resolves after subarachnoid hemorrhage (SAH). METHODS: Monkeys underwent angiography and right (n=17) or bilateral (n=8) SAH. Animals with bilateral SAH underwent angiography 1, 3, 5, and 7 days later. Animals with right SAH underwent angiography 7 days later. The clot was then not removed (n=5), removed and replaced with fresh clot (n=7), or removed and not replaced (n=5). At the same time on day 7, the removed clot (n=12) or fresh clot (n=5) was placed on the left side. Angiography was repeated every 2 days until day 14. RESULTS: SAH caused significant vasospasm on day 7 that resolved by day 14. Removal of clot on day 7 resulted in more rapid resolution of vasospasm. Placement of fresh clot onto arteries that had already been exposed to clot for 7 days produced vasospasm that persisted without resolving for an additional 7 days. Placement of 7-day-old clot from the right onto previously unexposed left arteries or of clot from blood removed from an animal 7 days after SAH caused significantly more rapid onset of vasospasm compared with de novo vasospasm. Microscopic examination of the clots showed they were surrounded by macrophages 7 days after SAH. Arterial compliance and contractility were reduced in relation to duration of the exposure of arteries to clot. CONCLUSIONS: Vasospasm resolves because of loss of subarachnoid blood clot. We hypothesize that reduced spasmogen release from the clot contributes to resolution of vasospasm. There was no response in the cerebral arteries that rendered them less responsive to the subarachnoid clot.
Document No.	11486119