サイトウ　ミネキ   Mineki Saito   齊藤　峰輝    所属   川崎医科大学  医学部 基礎医学　微生物学    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Unique directional motility of influenza C virus controlled by its filamentous morphology and short-range motions
掲載誌名	正式名：Journal of Virology 略　 称：J Virol ISSNコード：0022538X/10985514
掲載区分	国外
出版社	American society for microbiology
巻・号・頁	92(2)
著者・共著者	Sakai Tatsuya, Takagi Hiroaki, Muraki Yasushi, Saito Mineki
担当区分	最終著者
発行年月	2018/01
概要	Influenza virus motility is based on cooperation between two viral spike proteins, hemagglutinin (HA) and neuraminidase (NA), and is a major determinant of virus infectivity. To translocate a virus particle on the cell surface, HA molecules exchange viral receptors and NA molecules accelerate the receptor exchange of HA. This type of virus motility was recently identified in influenza A virus (IAV). To determine if other influenza virus types have a similar receptor-exchange mechanism-driven motility, we investigated influenza C virus (ICV) motility on a receptor-fixed glass surface. This system excludes receptor mobility, which makes it more optimal than a cell surface for demonstrating virus motility by receptor-exchange. Like IAV, ICV was observed to move across the receptor-fixed surface. However, in contrast with the random movement of IAV, a filamentous ICV strain, Ann Arbor/1/50 (AA), moved straight, in a directed manner, and at a constant rate, whereas a spherical ICV strain, Taylor/1233/47 (Taylor), moved randomly, similar to IAV. The AA and Taylor viruses each moved with a combination of gradual (crawling) and rapid (gliding) motions, but the lengths of crawling and gliding for the AA virus were shorter than those of the Taylor virus. Our findings indicate that, like IAV, ICV also has a motility that is driven by the receptor-exchange mechanism. However, compared with IAV movement, filamentous ICV movement is highly regulated in both direction and speed. Control of ICV movement is based on its specific motility employing short crawling and gliding motions as well as its own filamentous morphology.
DOI	doi: 10.1128/JVI.01522-17