Kei Miyano
   Department   Kawasaki Medical School  Kawasaki Medical School, Department of Natural Sciences,
   Position   Assistant Professor
Article types 原著
Language English
Peer review Peer reviewed
Title The rRNA synthesis inhibitor CX-5461 may induce autophagy that inhibits anticancer drug-induced cell damage to leukemia cells
Journal Formal name:Bioscience, Biotechnology, and Biochemistry
ISSN code:09168451/13476947
Domestic / ForeginForegin
Publisher Taylor & Francis Group
Author and coauthor Okamoto S, Miyano K, Kajikawa M, Yamauchi A, Kuribayashi F
Authorship Lead author,Corresponding author
Publication date 2020/08/15
Summary Autophagy induced in cancer cells during chemotherapy is classified into two types, which differ depending on the kind of cells or anticancer drugs. The first type of autophagy contributes to the death of cells treated with drugs. In contrast, the second type plays a crucial role in preventing anticancer drug-induced cell damages; the use of an autophagy inhibitor is considered effective in improving the efficacy of chemotherapy. Thus, it is important to determine which type of autophagy is induced during chemotherapy. Here, we showed that a novel inhibitor of RNA polymerase I, suppresses growth, induces cell cycle arrest and promotes apoptosis in leukemia cell lines. The number of apoptotic cells induced by co-treatment with CX-5461 and chloroquine, an autophagy inhibitor, increased compared with CX-5461 alone. Thus, the autophagy which may be induced by CX-5461 was the second type.