Shuichi Hayashi
   Department     Kawasaki Medical School, Department of Anatomy,
   Position   Associate Professor
Article types 原著
Language English
Peer review Peer reviewed
Title Expression patterns of Xenopus FGF Receptor-Like 1/nou-darake in early Xenopus development resemble those of planarian nou-darake and Xenopus FGF8.
Journal Formal name:Developmental Dynamics
Domestic / ForeginForegin
Volume, Issue, Page 230(4),700-707頁
Author and coauthor Hayashi, S., Itoh, M., Taira, S., Agata, K. and Taira, M.
Publication date 2004
Summary Fibroblast growth factors (FGFs) mediate many cell-to-cell signaling events during early development. Nou-darake (ndk), a gene encoding an FGF receptor (FGFR)-like molecule, was found to be highly and specifically expressed in the head region of the planarian Dugesia japonica, and its functional analyses provided strong molecular evidence for the existence of a brain-inducing circuit based on the FGF signaling pathway. To analyze the role of ndk during vertebrate development, we isolated the Xenopus ortholog of ndk, the vertebrate FGFR-like 1 gene (XFGFRL1). Expression of XFGFRL1/Xndk was first detected in the anterior region at the late gastrula stage and dramatically increased at the early neurula stage in an overall anterior mesendodermal region, including the prechordal plate, paraxial mesoderm, anterior endoderm, and archenteron roof. This anterior expression pattern resembles that of ndk in planarians, suggesting that the expression of FGFRL1/ndk is conserved in evolution between these two distantly diverged organisms. During the tail bud stages, XFGFRL1/Xndk expression was detected in multiple regions, including the forebrain, eyes, midbrain-hindbrain boundary, otic vesicles, visceral arches, and somites. In many of these regions, XFGFRL1/Xndk was coexpressed with XFGF8, indicating that XFGFRL1/Xndk is a member of the XFGF8 synexpression group, which includes sprouty, sef, and isthmin.