Akira Yamauchi
Department Kawasaki Medical School Kawasaki Medical School, Department of Biochemistry, Position Professor |
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Article types | 原著 |
Language | English |
Peer review | Peer reviewed |
Title | Synthesis of 4-aroyl-5-arylpyrazoles and 4-aroyl-3-arylpyrazoles via the reaction of enaminodiketones with substituted hydrazines |
Journal | Formal name:Heterocycles Abbreviation:Heterocycles ISSN code:03855414 |
Domestic / Foregin | Foregin |
Publisher | The Japan Institute of Heterocyclic Chemistry |
Volume, Issue, Page | 100(1),pp.25-45 |
Total page number | 21 |
Author and coauthor | Rika Kotouge, Takashi Nishiyama, Akira Yamauchi, Kanako Ono, Noriyuki Hatae, Tsutomu Oikawa, Satoshi Hibino, and Tominari Choshi |
Publication date | 2020 |
Summary | Pyrazole is a five-membered heterocyclic compound and is one of the important heterocycles in the fields of medicine and pharmacology. Here, we demonstrate the reactivity of symmetrical enaminodiketones 8–14 with substituted hydrazines. When using alkylhydrazines, if the substituent size of the alkyl group is small, it is possible to selectively synthesize 1-substituted 4-aroyl-5-arylpyrazoles and their regioisomers, 1-substituted 4-aroyl-3-arylpyrazoles, by choosing the solvent (EtOH or toluene). When they react with bulky substituted hydrazines (e.g., cyclohexyl, phenyl, or pyridyl), only 1-substituted 4-aroyl-5-arylpyrazoles are selectively obtained. |
DOI | 10.3987/COM-19-14096 |