ヤマウチ アキラ
  山内 明
   所属   川崎医科大学  医学部 基礎医学 生化学
   職種   教授
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Relationship between macrophage differentiation and the chemotactic activity toward damaged myoblast cells
掲載誌名 正式名:Journal of Immunological Methods
略  称:J Immunol Methods
巻・号・頁 393(1-2),61-69頁
著者・共著者 Masataka Uchida, Eri Oyanagi, Motohiko Miyachi, Akira Yamauchi, Hiromi Yano
発行年月 2013/07
概要 We investigated the effect of macrophage differentiation on the chemotactic activity to invade local damaged myoblasts using in vitro models of muscle injury. We found that: 1) the chemotactic activity of macrophages toward areas of damaged myoblasts might be induced more by live myoblasts than dead ones, 2) the chemotactic activity of macrophages is not due to velocity, but depends on the directionality toward damaged myoblast cells, and 3) macrophage differentiation strongly influence the chemotactic activity toward damaged myoblast cells through the expression of CCR2 and/or F-actin.
DOI 10.1016/j.jim.2013.04.007