Takehiro Nakamura    Department   Kawasaki Medical School  Kawasaki Medical School, Department of Physiology 2,    Position   Professor
Article types	原著
Language	English
Peer review	Peer reviewed
Title	Stage- and region-specific cyclooxygenase expression and effects of a selective COX-1 inhibitor in the mouse amygdala kindling model.
Journal	Formal name：Neurosciecen Research Abbreviation：Neurosci Res
Domestic / Foregin	Foregin
Volume, Issue, Page	65(1),pp.79-87
Author and coauthor	Tanaka Shinji, Nakamura Takehiro, Sumitani Kazunori, Takahashi Fumio, Konishi Ryoji, Itano Toshifumi, Miyamoto Osamu
Authorship	2nd author
Publication date	2009/01/11
Summary	In an attempt to elucidate the involvement of cyclooxygenase (COX) enzymes, particularly COX-1, in epileptogenesis, the localization of COX-1 and COX-2 expression in the mouse kindling model was analyzed by immunohistochemistry. COX-2 was predominantly observed in brain neurons and its concentration in the hippocampus increased with progressing seizures, as reported previously. COX-1 was predominant in microglia and its concentration was also enhanced in the hippocampus and areas around the third ventricle during the progression of seizures. These regions are thought to play an important role in the propagation of limbic seizures. Moreover, the administration of SC-560 (a selective COX-1 inhibitor) or indomethacin (a non-selective COX inhibitor) retarded the progress of seizures. Although the precise function of COX-positive cells in microglia and elsewhere is not clear, our results suggest that COX-1 as well as COX-2 may be involved in epileptogenesis, and that certain COX inhibitors can potentially prevent the occurrence of seizures.