ナカムラ　タケヒロ   Takehiro Nakamura   中村　丈洋    所属   川崎医科大学  医学部 基礎医学　生理学2    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Stage- and region-specific cyclooxygenase expression and effects of a selective COX-1 inhibitor in the mouse amygdala kindling model.
掲載誌名	正式名：Neurosciecen Research 略　 称：Neurosci Res
掲載区分	国外
巻・号・頁	65(1),pp.79-87
著者・共著者	Tanaka Shinji, Nakamura Takehiro, Sumitani Kazunori, Takahashi Fumio, Konishi Ryoji, Itano Toshifumi, Miyamoto Osamu
担当区分	2nd著者
発行年月	2009/01/11
概要	In an attempt to elucidate the involvement of cyclooxygenase (COX) enzymes, particularly COX-1, in epileptogenesis, the localization of COX-1 and COX-2 expression in the mouse kindling model was analyzed by immunohistochemistry. COX-2 was predominantly observed in brain neurons and its concentration in the hippocampus increased with progressing seizures, as reported previously. COX-1 was predominant in microglia and its concentration was also enhanced in the hippocampus and areas around the third ventricle during the progression of seizures. These regions are thought to play an important role in the propagation of limbic seizures. Moreover, the administration of SC-560 (a selective COX-1 inhibitor) or indomethacin (a non-selective COX inhibitor) retarded the progress of seizures. Although the precise function of COX-positive cells in microglia and elsewhere is not clear, our results suggest that COX-1 as well as COX-2 may be involved in epileptogenesis, and that certain COX inhibitors can potentially prevent the occurrence of seizures.