Shuya Yano
Department Kawasaki Medical School Kawasaki Medical School, Department of Digestive Surgery, Position Assistant Professor |
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Article types | 症例報告 |
Language | English |
Peer review | Peer reviewed |
Title | Long-term survival without recurrence after surgery for gastric yolk sac tumor-like carcinoma: a case report. |
Journal | Formal name:Surgical case reports Abbreviation:Surg Case Rep ISSN code:21987793/21987793 |
Domestic / Foregin | Foregin |
Volume, Issue, Page | 7(1),pp.111 |
Author and coauthor | Umeda Hibiki, Kikuchi Satoru, Kuroda Shinji, Yano Shuya, Tanaka Takehiro, Noma Kazuhiro, Nishizaki Masahiko, Kagawa Shunsuke, Umeda Yuzo, Fujiwara Toshiyoshi |
Publication date | 2021/05 |
Summary | BACKGROUND:Gastric yolk sac tumor (YST)-like carcinoma is extremely rare, and its prognosis is poor, because most patients have widespread metastases at the time of diagnosis. We report a case of gastric YST-like carcinoma with an adenocarcinoma component without metastases in which curative resection was performed.CASE PRESENTATION:A 77-year-old man complaining of melena and dizziness due to anemia was diagnosed with poorly differentiated adenocarcinoma in the gastric cardia, with a benign ulcer in the gastric body. He underwent total gastrectomy with D2 lymph node dissection for the tumor. Histological examination of the resected specimens revealed a mixture of reticular and glandular neoplastic components morphologically. In the reticular area, an endodermal sinus pattern and some Schiller-Duval bodies were confirmed. Gastric YST-like carcinoma with adenocarcinoma components, T2N0M0 Stage IB, was diagnosed. Immunohistochemical analysis showed that the YST was positive for carcinoembryonic antigen (CEA), alpha-fetoprotein (AFP) and p53. In contrast, the adenocarcinoma was positive for p53 and negative for CEA and AFP. The patient remained healthy as of 7 years postoperatively, with no recurrence.CONCLUSIONS:Routine medical examinations or endoscopic examinations for accidental symptom may be helpful for early diagnosis and good prognosis for gastric YST-like carcinoma, although the prognosis is generally poor. |
DOI | 10.1186/s40792-021-01199-3 |
PMID | 33956241 |