Shuya Yano
   Department   Kawasaki Medical School  Kawasaki Medical School, Department of Digestive Surgery,
   Position   Assistant Professor
Article types 症例報告
Language English
Peer review Peer reviewed
Title Long-term survival without recurrence after surgery for gastric yolk sac tumor-like carcinoma: a case report.
Journal Formal name:Surgical case reports
Abbreviation:Surg Case Rep
ISSN code:21987793/21987793
Domestic / ForeginForegin
Volume, Issue, Page 7(1),pp.111
Author and coauthor Umeda Hibiki, Kikuchi Satoru, Kuroda Shinji, Yano Shuya, Tanaka Takehiro, Noma Kazuhiro, Nishizaki Masahiko, Kagawa Shunsuke, Umeda Yuzo, Fujiwara Toshiyoshi
Publication date 2021/05
Summary BACKGROUND:Gastric yolk sac tumor (YST)-like carcinoma is extremely rare, and its prognosis is poor, because most patients have widespread metastases at the time of diagnosis. We report a case of gastric YST-like carcinoma with an adenocarcinoma component without metastases in which curative resection was performed.CASE PRESENTATION:A 77-year-old man complaining of melena and dizziness due to anemia was diagnosed with poorly differentiated adenocarcinoma in the gastric cardia, with a benign ulcer in the gastric body. He underwent total gastrectomy with D2 lymph node dissection for the tumor. Histological examination of the resected specimens revealed a mixture of reticular and glandular neoplastic components morphologically. In the reticular area, an endodermal sinus pattern and some Schiller-Duval bodies were confirmed. Gastric YST-like carcinoma with adenocarcinoma components, T2N0M0 Stage IB, was diagnosed. Immunohistochemical analysis showed that the YST was positive for carcinoembryonic antigen (CEA), alpha-fetoprotein (AFP) and p53. In contrast, the adenocarcinoma was positive for p53 and negative for CEA and AFP. The patient remained healthy as of 7 years postoperatively, with no recurrence.CONCLUSIONS:Routine medical examinations or endoscopic examinations for accidental symptom may be helpful for early diagnosis and good prognosis for gastric YST-like carcinoma, although the prognosis is generally poor.
DOI 10.1186/s40792-021-01199-3
PMID 33956241