ヤノ　シュウヤ   Shuya Yano   矢野　修也    所属   川崎医科大学  医学部 臨床医学　臨床腫瘍学    職種   臨床助教11年
論文種別	症例報告
言語種別	英語
査読の有無	査読あり
表題	Long-term survival without recurrence after surgery for gastric yolk sac tumor-like carcinoma: a case report.
掲載誌名	正式名：Surgical case reports 略　 称：Surg Case Rep ISSNコード：21987793/21987793
掲載区分	国外
巻・号・頁	7(1),pp.111
著者・共著者	Umeda Hibiki, Kikuchi Satoru, Kuroda Shinji, Yano Shuya, Tanaka Takehiro, Noma Kazuhiro, Nishizaki Masahiko, Kagawa Shunsuke, Umeda Yuzo, Fujiwara Toshiyoshi
発行年月	2021/05
概要	BACKGROUND:Gastric yolk sac tumor (YST)-like carcinoma is extremely rare, and its prognosis is poor, because most patients have widespread metastases at the time of diagnosis. We report a case of gastric YST-like carcinoma with an adenocarcinoma component without metastases in which curative resection was performed.CASE PRESENTATION:A 77-year-old man complaining of melena and dizziness due to anemia was diagnosed with poorly differentiated adenocarcinoma in the gastric cardia, with a benign ulcer in the gastric body. He underwent total gastrectomy with D2 lymph node dissection for the tumor. Histological examination of the resected specimens revealed a mixture of reticular and glandular neoplastic components morphologically. In the reticular area, an endodermal sinus pattern and some Schiller-Duval bodies were confirmed. Gastric YST-like carcinoma with adenocarcinoma components, T2N0M0 Stage IB, was diagnosed. Immunohistochemical analysis showed that the YST was positive for carcinoembryonic antigen (CEA), alpha-fetoprotein (AFP) and p53. In contrast, the adenocarcinoma was positive for p53 and negative for CEA and AFP. The patient remained healthy as of 7 years postoperatively, with no recurrence.CONCLUSIONS:Routine medical examinations or endoscopic examinations for accidental symptom may be helpful for early diagnosis and good prognosis for gastric YST-like carcinoma, although the prognosis is generally poor.
DOI	10.1186/s40792-021-01199-3
PMID	33956241