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ヤノ シュウヤ
Shuya Yano
矢野 修也 所属 川崎医科大学 医学部 臨床医学 消化器外科学 職種 講師 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Hyperthermia generated by magnetic nanoparticles for effective treatment of disseminated peritoneal cancer in an orthotopic nude-mouse model. |
| 掲載誌名 | 正式名：Cell cycle (Georgetown, Tex.) 略 称：Cell Cycle ISSNコード：15514005/15514005 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 20(12),pp.1122-1133 |
| 著者・共著者 | Matsumi Yuki, Kagawa Tetsuya, Yano Shuya, Tazawa Hiroshi, Shigeyasu Kunitoshi, Takeda Sho, Ohara Toshiaki, Aono Hiromichi, Hoffman Robert M, Fujiwara Toshiyoshi, Kishimoto Hiroyuki |
| 発行年月 | 2021/06 |
| 概要 | Magnetic hyperthermia (MHT), which combines magnetic nanoparticles (MNPs) with an alternating magnetic field (AMF), holds promise as a cancer therapy. There have been many studies about hyperthermia, most of which have been performed by direct injection of MNPs into tumor tissues. However, there have been no reports of treating peritoneal disseminated disease with MHT to date. In the present study, we treated peritoneal metastasis of gastric cancer with MHT using superparamagnetic iron oxide (Fe3O4) nanoparticle (SPION) coated with carboxydextran as an MNP, in an orthotopic mouse model mimicking early peritoneal disseminated disease of gastric cancer. SPIONs of an optimal size were intraperitoneally administered, and an AMF (390 kHz, 28 kAm-1) was applied for 10 minutes, four times every three days. Three weeks after the first MHT treatment, the peritoneal metastases were significantly inhibited compared with the AMF-alone group or the untreated-control group. The results of the present study show that MHT can be applied as a new treatment option for disseminated peritoneal gastric cancer.Abbreviations: AMF: alternating magnetic field; Cy1: cytology-positive; DMEM: Dulbecco's Modified Eagle's Medium; FBS: fetal bovine serum; H&E: hematoxylin and eosin; HIPEC: hyperthermic intraperitoneal chemotherapy; MEM: Minimum Essential Medium; MHT: magnetic hyperthermia; MNPs: magnetic nanoparticles; P0: macroscopic peritoneal dissemination; RFP: red fluorescent protein; SPION: superparamagnetic iron oxide (Fe3O4) nanoparticle. |
| DOI | 10.1080/15384101.2021.1919441 |
| PMID | 34110969 |