Haruyo Yamanishi    Department   Kawasaki Medical School  Kawasaki Medical School, Department of Anatomy,    Position   Assistant Professor
Article types	原著
Language	English
Peer review	Peer reviewed
Title	Marked Changes in Lamellar Granule and Trans-Golgi Network Structure Occur during Epidermal Keratinocyte Differentiation.
Journal	Formal name：The Journal of investigative dermatology ISSN code：15231747/0022202X
Domestic / Foregin	Foregin
Volume, Issue, Page	139,pp.352-359
Author and coauthor	Yamanishi H, Soma T, Kishimoto J, Hibino T, Ishida-Yamamoto A
Publication date	2019/02
Summary	Epidermal lamellar granules transport various lipids, proteins, and protein inhibitors from the trans-Golgi network to the extracellular space, and play an important role in skin barrier formation. We elucidated the 3-dimensional structure of lamellar granules and the trans-Golgi network in normal human skin by focused ion beam scanning electron microscopy. Reconstructed focused ion beam scanning electron microscopy 3-dimensional images revealed that the overall lamellar granule structure changed from vesicular to reticular within the second layer of the stratum granulosum. Furthermore, the trans-Golgi network was well developed within this layer and spread through the cytoplasm with branched, tubular structures that connected to lamellar granules. Our study reveals the unique overall 3-dimensional structure of lamellar granules and the trans-Golgi network within the cells of the epidermis, and provides the basis for an understanding of the skin barrier formation.
URL for researchmap	https://www.sciencedirect.com/science/article/pii/S0022202X1832579X?via%3Dihub