Hiroyoshi Doihara
   Department   Kawasaki Medical School  Kawasaki Medical School, Department of General Surgery,
   Position   Professor with Special Assignment
Article types 原著
Language English
Peer review Peer reviewed
Title Evaluation of Prognosis of Juvenile Differentiated Thyroid Carcinoma.
Journal Formal name：Acta medica Okayama
Abbreviation：Acta Med Okayama
ISSN code：0386300X/0386300X
Domestic / ForeginForegin
Volume, Issue, Page 74(5),pp.401-406
Author and coauthor Tsukioki Takahiro, Shien Tadahiko, Ohtani Yusuke, Fujihara Miwa, Suzuki Yoko, Kajihara Yukiko, Hatono Minami, Kawada Kengo, Kochi Mariko, Iwamoto Takayuki, Ikeda Hirokuni, Taira Naruto, Doihara Hiroyoshi
Publication date 2020/10
Summary Differentiated thyroid carcinoma (DTC) in juvenile patients is often an extensive and aggressive disease with a high frequency of recurrence. However, the prognosis is excellent, with a low mortality rate even when advanced disease is present, although prognostic factors and treatment strategy remain uncertain. Between April 2004 and March 2017, 33 juvenile patients (< 30 years old) were diagnosed with DTC and treated at our institution. We retrospectively investigated prognosis and factors including sex, reason for discovery, treatment, pathological factors and treatment progress to clarify the risk factors. All patients underwent curative surgical treatment. Pathologically, lymph node metastasis was identified in 25 patients (75%). Thirteen patients (39%) had bilateral cervical metastasis. In addition, 9 (27%) had more than 10 metastatic lymph nodes. The 2 patients with more than 20 metastatic lymph nodes were treated with radioactive iodine (RAI). Five patients (15%) had local recurrences and received surgery. There have been no further recurrences or deaths. However, no factors were determined to significantly predict the recurrence of juvenile DTC. Local recurrent disease was treated with surgery and/or RAI until remission, and survival was excellent in juvenile DTC.
DOI 10.18926/AMO/60799
PMID 33106695