Hiroyoshi Doihara    Department   Kawasaki Medical School  Kawasaki Medical School, Department of General Surgery,    Position   Professor with Special Assignment
Article types	原著
Language	English
Peer review	Peer reviewed
Title	Influence of breast density on breast cancer risk: a case control study in Japanese women.
Journal	Formal name：Breast cancer (Tokyo, Japan) Abbreviation：Breast Cancer ISSN code：18804233/13406868
Domestic / Foregin	Foregin
Volume, Issue, Page	27(2),pp.277-283
Author and coauthor	Nishiyama Keiko, Taira Naruto, Mizoo Taeko, Kochi Mariko, Ikeda Hirokuni, Iwamoto Takayuki, Shien Tadahiko, Doihara Hiroyoshi, Ishihara Setuko, Kawai Hiroshi, Kawasaki Kensuke, Ishibe Yoichi, Ogasawara Yutaka, Toyooka Shinichi
Publication date	2020/03
Summary	BACKGROUND:Mammography is the standard examination for breast cancer screening of woman aged ≥ 40 years. High breast density on mammography indicates that mammary gland parenchyma occupy a high percentage of the breast. The objective of this study was to investigate factors associated with breast density and the risk of high breast density for breast cancer.METHODS:A multicenter case-control study was performed in 530 patients and 1043 controls. Breast density was classified as C1-C4 using the Breast Imaging Reporting and Data System (BI-RADS). Clinical factors were obtained from questionnaires or medical records, and the influence of each factor (breast density, menopausal status, body mass index (BMI), parity, presence or absence of breastfeeding history, age at menarche, age at first birth, and familial history of breast cancer) on breast cancer risk in all patients was calculated as an age-adjusted odds ratio (OR). Multivariate logistic regression analyses were then performed in all patients and in pre- and postmenopausal and BMI-stratified groups using factors with a significant age-adjusted OR as adjustment factors.RESULTS:Age-adjusted ORs for breast cancer were significant for breast density, BMI, parity, and breast feeding, but not for age at menarche, age at first birth, or family history of breast cancer. In multivariate analysis, there was a significant correlation between breast density and breast cancer in postmenopausal women (OR for C1 vs. C2 1.90 [95% CI 1.34-2.70]; C1 vs. C4 2.85 [95% CI 1.10-7.16]). This correlation was also significant in patients in the third BMI quartile (22.3-24.5 kg/m2) (OR for C1 vs. C4 8.76 [95% CI 2.38-42.47]); and fourth BMI quartile (>24.5 kg/m2) (OR for C1 vs. C2 1.92 [95% CI 1.17-3.15]; C1 vs. C4 11.89 [95% CI 1.56-245.17]).
DOI	10.1007/s12282-019-01018-6
PMID	31650498