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Hiroyoshi Doihara
Department Kawasaki Medical School Kawasaki Medical School, Department of General Surgery, Position Professor with Special Assignment |
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| Article types | 原著 |
| Language | English |
| Peer review | Peer reviewed |
| Title | The efficacy and feasibility of dose-dense sequential chemotherapy for Japanese patients with breast cancer. |
| Journal | Formal name：Breast cancer (Tokyo, Japan) Abbreviation：Breast Cancer ISSN code：18804233/13406868 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 25(6),pp.717-722 |
| Author and coauthor | Takabatake Daisuke, Kajiwara Yukiko, Ohtani Shoichiro, Itano Yoko, Yamamoto Mari, Kubo Shinichiro, Ikeda Masahiko, Takahashi Mina, Hara Fumikata, Aogi Kenjiro, Ohsumi Shozo, Ogasawara Yutaka, Nishiyama Yoshitaka, Hikino Hajime, Matsuoka Kinya, Takahashi Yuko, Shien Tadahiko, Taira Naruto, Doihara Hiroyoshi |
| Publication date | 2018/11 |
| Summary | BACKGROUND:Perioperative dose-dense chemotherapy (DDCT) with granulocyte-colony stimulating factor (G-CSF) prophylaxis is a standard treatment for patients with high-risk breast cancer. The approval of this approach in Japan led to the widespread adoption of DDCT, despite limited efficacy and safety data among Japanese patients. We evaluated the efficacy and safety of neoadjuvant DDCT for Japanese patients with breast cancer.METHODS:This prospective, multicenter, phase II study evaluated 52 women with operable human epidermal growth factor receptor 2-negative breast cancer and axillary lymph node metastasis. Neoadjuvant DDCT (adriamycin plus cyclophosphamide or epirubicin plus cyclophosphamide followed by paclitaxel) was administrated every 2 weeks with G-CSF support. The study endpoints were the rates of pathological complete response (pCR), febrile neutropenia, treatment completion, toxicities, and the relative dose intensity (RDI).RESULTS:The pCR rate was 21.9% (9/41) and the triple-negative (TN) subtype was significantly associated with a high pCR rate (triple-negative: 53.3% vs. luminal A: 7.7% and luminal B: 0%; p = 0.003). The treatment completion rate was 80.8% (42/52) and the average RDI was 98.9%. Most adverse events were manageable and tolerable. Six patients (11.5%) developed febrile neutropenia. Grade 3-4 adverse events were slightly more common among older patients (57%) with a low protocol completion rate (≥ 65 years: 42.9% vs. <65 years: 86.7%, p = 0.0062).CONCLUSION:The pCR rate for DDCT was similar to that of standard chemotherapy, although it was remarkably effective for the TN subtype. DDCT may be feasible for Japanese patients with breast cancer although caution is needed for older patients. |
| DOI | 10.1007/s12282-018-0877-1 |
| PMID | 29948957 |