Hiroyoshi Doihara    Department   Kawasaki Medical School  Kawasaki Medical School, Department of General Surgery,    Position   Professor with Special Assignment
Article types	原著
Language	English
Peer review	Peer reviewed
Title	Current Multidisciplinary Approach to Fertility Preservation for Breast Cancer Patients.
Journal	Formal name：Acta medica Okayama Abbreviation：Acta Med Okayama ISSN code：0386300X/0386300X
Domestic / Foregin	Foregin
Volume, Issue, Page	72(2),pp.137-142
Author and coauthor	Takahashi Yuko, Shien Tadahiko, Sakamoto Ai, Tsuyumu Yuko, Yoshioka Ryo, Uno Maya, Hatono Minami, Kochi Mariko, Kawada Kengo, Tsukioki Takahiro, Iwamoto Takayuki, Ikeda Hirokuni, Taira Naruto, Matsuoka Junji, Nakatsuka Mikiya, Doihara Hiroyoshi
Publication date	2018/04
Summary	Adverse effects on fertility are a significant problem for premenopausal breast cancer patients. Since April 2009, we have been referring young patients for fertility counseling provided by a multidisciplinary team. Here we evaluated the efficacy and safety of our current fertility preservation approach. We retrospectively analyzed the cases of 277 patients < 45 years old at diagnosis, which was made between 2009 and 2016. Seventy-two (26%) patients received fertility counseling. Seventeen (6%) of the 277 patients decided to preserve their fertility before starting adjuvant systemic therapy. Six (35%) patients underwent oocyte cryopreservation, and 11 (65%) married patients opted for embryo cryopreservation. There were no pregnancies among the patients undergoing oocyte cryopreservation, whereas 3 (27%) of the patients who opted for embryo cryopreservation became pregnant. Two (12%) patients stopped endocrine therapy after 2 years in an effort to become pregnant, but their breast cancers recurred. Though the problem of fertility loss for breast cancer patients is important and we should assess the infertility risk for all patients, we should also consider the prognosis. In June 2016, we launched a prospective multicenter cohort study to evaluate the efficacy and safety of fertility preservation in greater detail.
DOI	10.18926/AMO/55854
PMID	29674762