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Naruto Taira
Department Kawasaki Medical School Kawasaki Medical School, Department of Breast and Thyroid Surgery, Position Professor |
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| Article types | 原著 |
| Language | English |
| Peer review | Peer reviewed |
| Title | Minimal important differences of EORTC QLQ-C30 for metastatic breast cancer patients: Results from a randomized clinical trial. |
| Journal | Formal name：Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation Abbreviation：Qual Life Res ISSN code：15732649/09629343 |
| Domestic / Foregin | Foregin |
| Publisher | Springer |
| Volume, Issue, Page | 31(6),pp.1829-1836 |
| Author and coauthor | Kawahara Takuya, Taira Naruto, Shiroiwa Takeru, Hagiwara Yasuhiro, Fukuda Takashi, Uemura Yukari, Mukai Hirofumi |
| Authorship | 2nd author |
| Publication date | 2022/06 |
| Summary | PURPOSE:To establish minimal important differences (MIDs) for the European Organisation for Research and Treatment for Cancer Quality of life Questionnaire core 30 (EORTC QLQ-C30) in patients with metastatic breast cancer.METHODS:The dataset was obtained from the SELECT BC-CONFIRM randomized clinical trial. Anchors obtained from patients (transition items) and clinicians (performance status) were used for anchor-based methods. Anchors obtained through 6 months after starting treatment were used for this analysis. Correlation coefficients of anchor and change in QLQ-C30 and effect size were used to qualify for estimating MIDs. Mean change method and generalized estimating equation were applied to estimate MIDs. Distribution-based methods were used for comparison.RESULTS:We analyzed a dataset of 154 metastatic breast cancer patients. MIDs were estimated in 8 of 15 scales of QLQ-C30. Estimated MIDs for within-group improvement varied from 7 to 15 and those for deterioration varied from - 7 to - 17. Estimated MIDs for between-group improvement varied from 5 to 11 and those for deterioration varied from - 5 to - 8 across QLQ-C30 scales. Patient-reported anchors were more susceptible to early changes in health status than clinician-reported anchors.CONCLUSION:We provided the MIDs of the QLQ-C30 using both patient- and clinicians-reported anchors measured in a randomized trial of Japanese patients with metastatic breast cancer. We recommend patient-reported anchors for anchor-based estimation of MID. Our results can aid patients and clinicians, as well as researchers, in the interpretation of QLQ-C30. |
| DOI | 10.1007/s11136-021-03074-y |
| PMID | 34982354 |