Naruto Taira
   Department   Kawasaki Medical School  Kawasaki Medical School, Department of Breast and Thyroid Surgery,
   Position   Professor
Article types 原著
Language English
Peer review Peer reviewed
Title A Correlation Analysis Between Metabolism-related Genes and Treatment Response to S-1 as First-line Chemotherapy for Metastatic Breast Cancer: The SELECT BC-EURECA Study.
Journal Formal name：Clinical breast cancer
Abbreviation：Clin Breast Cancer
ISSN code：19380666/15268209
Domestic / ForeginForegin
Volume, Issue, Page 21(5),pp.450-457
Author and coauthor Takashima Tsutomu, Hara Fumikata, Iwamoto Takayuki, Uemura Yukari, Ohsumi Shozo, Yotsumoto Daisuke, Hozumi Yasuo, Watanabe Takanori, Saito Tsuyoshi, Watanabe Ken-Ichi, Tsurutani Junji, Toyama Tatsuya, Akabane Hiromitsu, Nishimura Reiki, Taira Naruto, Ohashi Yasuo, Mukai Hirofumi
Publication date 2021/10
Summary INTRODUCTION:The previous randomized phase 3 trial (SELECT BC) showed that S-1 as a first-line chemotherapy for metastatic breast cancer (MBC) is non-inferior to taxane with respect to overall survival. This study aimed to identify the usefulness of metabolism-related genes as predictive biomarkers for the response to S-1 compared with taxane using tumor tissue samples from the previous trial.   PATIENTS AND METHODS: In this SELECT BC-EURECA study, 147 patients with human epidermal growth factor 2 (HER2)-negative MBC who received either S-1 or taxane were evaluated. Formalin-fixed paraffin-embedded specimens were collected, and 14 genes involved in the pyrimidine metabolic pathway, estrogen receptor, progesterone receptor, HER2, Ki67, and beta-tubulin were measured using reverse transcription polymerase chain reaction in microdissected tumor specimens. The expression of each gene was categorized as low, intermediate, and high by tertile values.   RESULTS: Interaction tests to identify biomarkers for the response to S-1 compared with taxane, revealed the following as the top 3 biomarkers: RRM1 (P value = 0.24), GGH (P value = 0.25), and MTHFR (P value = 0.28). In the S-1 group, lower GGH and higher MTHFR expression were significantly correlated with better time to treatment failure. In the taxane group, there was no gene that was identified as a significant indicator of treatment failure.CONCLUSION:This biomarker analysis from SELECT BC did not identify any predictive biomarkers for the response to S-1 compared with taxane. Future studies with larger sample size and information on not only mRNA, but also protein and DNA for broad functional analyses are needed.
DOI 10.1016/j.clbc.2021.01.018
PMID 33685834