Sumie Asano
   Department   Kawasaki Medical School  Kawasaki Medical School, Department of Rheumatology,
   Position   Assistant Professor
Article types 原著
Language English
Peer review Peer reviewed
Title Risk Factors for Chronic Damage Accumulation Across Different Onset Eras in Systemic Lupus Erythematosus: A Cross-sectional Analysis of a Lupus Registry of Nationwide Institutions (LUNA).
Journal Formal name：Acta medica Okayama
Abbreviation：Acta Med Okayama
ISSN code：0386300X/0386300X
Domestic / ForeginDomestic
Volume, Issue, Page 74(3),pp.191-198
Author and coauthor Ohashi Keiji, Sada Ken-Ei, Asano Yosuke, Hayashi Keigo, Yamamura Yuriko, Asano Sumie Hiramatsu, Miyawaki Yoshia, Morishita Michiko, Katsuyama Eri, Watanabe Haruki, Tatebe Noriko, Narazaki Mariko, Matsumoto Yoshinori, Sunahori-Watanabe Katsue, Kawabata Tomoko, Yajima Nobuyuki, Wada Jun
Publication date 2020/06
Summary Chronic damage accumulation affects not only mortality but also quality of life in patients with systemic lupus erythematosus (SLE). Risk factors for chronic damage were explored in SLE through different onset eras. Two hundred forty-five patients at Okayama University Hospital and Showa University Hospital were divided into three groups based on the onset era: a past-onset group (onset before 1995; n=83), middle-onset group (1996-2009; n=88), and recent-onset group (after 2010; n=74). The mean Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI) score as an index of chronic damage was 1.93, 1.24, and 0.53 in the past-, middle-, and recent-onset groups, respectively. In the pastonset group, the total SDI score was significantly associated with glucocorticoid monotherapy by linear regression analysis (β-coefficient [β]=0.63; 95% confidence interval [CI], 0.21-1.05) and C-reactive protein levels (β=0.67; 95% CI, 0.27-1.07). In the middle-onset group, the total SDI score was significantly associated with the SLE Disease Activity Index at registration (β=0.09; 95% CI, 0.03-0.12). Reducing the accumulation of chronic damage in SLE patients might be possible with the concomitant use of immunosuppressants and tight control of disease activity.
DOI 10.18926/AMO/59949
PMID 32577016