所属 川崎医科大学 医学部 基礎医学 生化学
|表題||Review: The phagocyte NADPH oxidase and bacterial infections|
|掲載誌名||正式名：Kawasaki Medical Journal|
|著者・共著者||Akira YAMAUCHI, Akitoyo ICHINOSE, Chikage KAWAI, and Futoshi KURIBAYASHI|
|概要||Neutrophils play a crucial role in host defense against microbial infections.
During phagocytosis of invading bacteria or fungi, the phagocyte NADPH oxidase produces
superoxide. The importance of the oxidase is exemplified by the genetic disorder known as
chronic granulomatous disease (CGD). The neutrophils of CGD patients cannot produce
superoxide, with the result that affected infants and children suffer from severe recurrent
bacterial and fungal infections. Staphylococcus aureus and Aspergillus fumigatus often cause
life-threatening infections in these patients. The phagocyte NADPH oxidase is composed of
the plasma membrane protein (cytochrome b558) and cytosolic proteins. Cytochrome b558 is a
heterodimer consisting of the gp91phox and p22phox. The cytosolic proteins are p47phox, p67phox,
p40phox and a small G-protein, Rac. The oxidase is also expressed in peripheral eosinophils,
monocytes, B lymphocytes, and several cultured cell lines after differentiation other than
neutrophils. Here, we will consider and discuss the oxidase in relation to CGD.