Futoshi Kuribayashi
   Department     ,
Article types 原著
Language English
Peer review Peer reviewed
Title Human peripheral eosinophils have a specific mechanism to express gp91phox, the large subunit of cytochrome b558.
Journal Formal name:Biochemical and biophysical research communications
Abbreviation:Biochem. Biophys. Res. Commun.
ISSN code:0006-291X (Print)
Volume, Issue, Page 209(1),146-152頁
Author and coauthor Kuribayashi Futoshi, Suzuki Shoichi, Nakamura Michio, Matsumoto Tdashi, Tsuji Yoshiro.
Publication date 1995/04
Summary Eosinophils as well as neutrophils, monocytes and B lymphocytes are noted for lacking normal cytochrome b558 in patients with X-linked chronic granulomatous disease. The eosinophils of an X-linked male patient, however, fully expressed surface cytochrome b558, generated superoxide anion to a normal extent and definitely expressed the large subunit of cytochrome b558 (gp91-phox). His mononuclear leukocytes contained a diminished amount of gp91-phox mRNA with normal coding sequences. All the coding sequences and a putative poly (A) signal of his gp91-phox gene were normal. These results indicate that eosinophils have a specific mechanism to express gp91-phox and suggest that the mechanism lies at the transcriptional step of the gene.