川崎医科大学 教員情報   
     


  クリバヤシ フトシ   Futoshi Kuribayashi
  栗林 太
   所属   川崎医科大学  医学部 基礎医学 生化学
   職種   教授
論文種別 原著
単著/共著の別 共著
言語種別 英語
査読の有無 査読あり
表題 Human peripheral eosinophils have a specific mechanism to express gp91phox, the large subunit of cytochrome b558.
掲載誌名 正式名:Biochemical and biophysical research communications
略  称:Biochem. Biophys. Res. Commun.
ISSNコード:0006-291X (Print)
巻・号・頁 209(1),146-152頁
著者・共著者 Kuribayashi Futoshi, Suzuki Shoichi, Nakamura Michio, Matsumoto Tdashi, Tsuji Yoshiro.
発行年月 1995/04
概要 Eosinophils as well as neutrophils, monocytes and B lymphocytes are noted for lacking normal cytochrome b558 in patients with X-linked chronic granulomatous disease. The eosinophils of an X-linked male patient, however, fully expressed surface cytochrome b558, generated superoxide anion to a normal extent and definitely expressed the large subunit of cytochrome b558 (gp91-phox). His mononuclear leukocytes contained a diminished amount of gp91-phox mRNA with normal coding sequences. All the coding sequences and a putative poly (A) signal of his gp91-phox gene were normal. These results indicate that eosinophils have a specific mechanism to express gp91-phox and suggest that the mechanism lies at the transcriptional step of the gene.