所属 川崎医科大学 医学部 基礎医学 生化学
|表題||Human peripheral eosinophils have a specific mechanism to express gp91phox, the large subunit of cytochrome b558.|
|掲載誌名||正式名：Biochemical and biophysical research communications|
略 称：Biochem. Biophys. Res. Commun.
|著者・共著者||Kuribayashi Futoshi, Suzuki Shoichi, Nakamura Michio, Matsumoto Tdashi, Tsuji Yoshiro.|
|概要||Eosinophils as well as neutrophils, monocytes and B lymphocytes are noted for lacking normal cytochrome b558 in patients with X-linked chronic granulomatous disease. The eosinophils of an X-linked male patient, however, fully expressed surface cytochrome b558, generated superoxide anion to a normal extent and definitely expressed the large subunit of cytochrome b558 (gp91-phox). His mononuclear leukocytes contained a diminished amount of gp91-phox mRNA with normal coding sequences. All the coding sequences and a putative poly (A) signal of his gp91-phox gene were normal. These results indicate that eosinophils have a specific mechanism to express gp91-phox and suggest that the mechanism lies at the transcriptional step of the gene.|