Faculty Information - Kei Miyano

Present specialized field

BooK

Journal

Presentation

（Last updated : 2023-12-22 12:06:47）

Kei Miyano
Department Kawasaki Medical School Kawasaki Medical School, Department of Natural Sciences,

Position Assistant Professor

■ Present specialized field

Medical biochemistry

■ BooK

2010

The Nox family of NADPH oxidases that deliberately produce reactive oxygen species., In Free Radical Biology in Digestive Diseases, Front. Gastrointest. Res.

■ Journal

1.	2023/11	Hypoxia stabilizes the H2 O2 -producing oxidase Nox4 in cardiomyocytes via suppressing autophagy-related lysosomal degradation.
2.	2023/06	A basic charge cluster near the C-terminus of the cytoplasmic tail contributes to the molecular stability of human herpesvirus 8 E3 ubiquitin ligases
3.	2023/02/08	Hungarian Biochemists
4.	2023/01/18	Ca²⁺-binding-region-dependent cell surface localization of NADPH oxidase Nox5.
5.	2023/01/06	Characterization of missense mutations in the NADPH oxidase partner p22^phox in the A22° subtype of chronic granulomatous disease.
6.	2022/10/28	Importance of accessibility to the extracellular juxtamembrane stalk region of membrane protein for substrate recognition by viral ubiquitin ligase K5
7.	2022/09/29	Inhibition of pancreatic cancer-cell growth and metastasis in vivo by a pyrazole compound characterized as a cell-migration inhibitor by an in vitro chemotaxis assay
8.	2022/09/13	Regulation of Derlin-1-mediated degradation of NADPH oxidase partner p22^phox by thiol modification.
9.	2022/02	Fine definition of the epitopes on the human gp91^phox/NOX2 for the monoclonal antibodies CL-5 and 48
10.	2022/01/11	The downregulation of NADPH oxidase Nox4 during hypoxia in hemangioendothelioma cells: a possible role of p22^phox on Nox4 protein stability.
11.	2022/01/08	Coculture in vitro with endothelial cells induces cytarabine resistance of acute myeloid leukemia cells in a VEGF-A/VEGFR-2 signaling–independent manner
12.	2021/03/26	The efficient detection of membrane protein with immunoblotting: lessons from cold-temperature denaturation
13.	2020/09/28	Constitutive activity of NADPH oxidase 1 (Nox1) that promotes its own activity suppresses the colon epithelial cell migration
14.	2020/08/15	The rRNA synthesis inhibitor CX-5461 may induce autophagy that inhibits anticancer drug-induced cell damage to leukemia cells
15.	2020/07/02	The NADPH oxidase NOX4 promotes the directed migration of endothelial cells by stabilizing vascular endothelial growth factor receptor 2 protein
16.	2018/06	Differential cell surface recruitment of the superoxide-producing NADPH oxidases Nox1, Nox2 and Nox5: The role of the small GTPase Sar1.
17.	2016/12	TRPC3-GEF-H1 axis mediates pressure overload-induced cardiac fibrosis.
18.	2016/11	TRPC3 positively regulates reactive oxygen species driving maladaptive cardiac remodeling.
19.	2014/12	DOCK2 and DOCK5 Act Additively in Neutrophils To Regulate Chemotaxis, Superoxide Production, and Extracellular Trap Formation.
20.	2014/09	Arachidonic Acid Induces Direct Interaction of the p67phox-Rac Complex with the Phagocyte Oxidase Nox2, Leading to Superoxide Production.
21.	2014/06	Visualization of phagosomal hydrogen peroxide production by a novel fluorescent probe that is localized via SNAP-tag labeling.
22.	2014/01	N-linked glycosylation of the superoxide-producing NADPH oxidase Nox1.
23.	2012/11	Assessment of the role for Rho family GTPases in NADPH oxidase activation.
24.	2012/05	Atypical membrane-embedded phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2)-binding site on p47phox phox homology (PX) domain revealed by NMR.
25.	2012/04	Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2.
26.	2011/10	Selectively induced apoptosis in human neutrophils in the presence of oxidative phenoxazines, 2-amino-4,4a-dihydryo-4a-7H-phenoxazine-3-one and 2-aminophenoxazine-3-one, preceded by decrease of intracellular pH, depolarization of the mitochondria, and inhibition of superoxide.
27.	2010/10	A conserved region between the TPR and activation domains of p67phox participates in activation of the phagocyte NADPH oxidase.
28.	2010/05	Membrane phospholipid metabolism during phagocytosis in human neutrophils.
29.	2009/08	The domain organization of p67phox, a protein required for activation of the superoxide-producing NADPH oxidase in phagocytes.
30.	2009/08	The insert region of the Rac GTPases is dispensable for activation of superoxide-producing NADPH oxidases.
31.	2009/04	A region N-terminal to the tandem SH3 domain of p47phox plays a crucial role in the activation of the phagocyte NADPH oxidase.
32.	2009/02	Role for the first SH3 domain of p67phox in activation of superoxide-producing NADPH oxidases.
33.	2007/09	p40phox as an alternative organizer to p47phox in Nox2 activation: A new mechanism involving an interaction with p22phox.
34.	2007/09	Role of the small GTPase Rac in p22phox-dependent NADPH oxidases.
35.	2006/08	Direct involvement of the small GTPase Rac in activation of the superoxide-producing NADPH oxidase Nox1.
36.	2005/12	A new type of O(2)(-)-generating tool for oxidative stress studies by remodeling neutrophil NADPH oxidase.
37.	2005/12	Molecular composition and regulation of the Nox family NAD(P)H oxidases.
38.	2005/06	The NADPH oxidase Nox3 constitutively produces superoxide in a p22phox-dependent manner: its regulation by oxidase organizers and activators.
39.	2004/11	Inactivation of neutrophil NADPH oxidase upon dilution and its prevention by cross-link and fusion of phox proteins.
40.	2004/07	Activation of the flavoprotein domain of gp91phox upon interaction with N-terminal p67phox (1-210) and the Rac complex.
41.	2003/08	A new role of Pro-73 of p47phox in the activation of neutrophil NADPH oxidase.
42.	2003/01	Remarkable stabilization of neutrophil NADPH oxidase using RacQ61L and a p67phox-p47phox fusion protein.
43.	2001/11	A fusion protein between rac and p67phox (1-210) reconstitutes NADPH oxidase with higher activity and stability than the individual components.
44.	2001/07	Fused p47phox and p67phox truncations efficiently reconstitute NADPH oxidase with higher activity and stability than the individual components.
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■ Presentation

1.	2023/12/08	Protein stabilization mechanisms of reactive oxygen species-producing NADPH oxidase （Poster notice，General）
2.	2011/09/06	The Nox family NADPH oxidases involved in host defense and signal transduction （Speech，Panelist at Symposium/Workshop (Appointed)）
3.	2010/06/06	Role for the N-terminal transmembrane and C-terminal cytosolic moieties of Nox-family NADPH oxidases. （Poster notice，General）
4.	2010/06/06	Structure and regulation of Nox family NADPH oxidases that deliberately produce reactive oxygen species （Speech，Panelist at Symposium/Workshop (Appointed)）
5.	2006/10/16	Direct Involvement of the Small GTPase Rac in Activation of the Superoxide- Producing NADPH Oxidase Nox1. （Poster notice，General）
6.	2006/06/18	Direct Involvement of the Small GTPase Rac in Activation of the Superoxide- Producing NADPH Oxidase Nox1. （Poster notice，General）
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