教員情報 - 増田　清士

現在の専門分野

学術雑誌

学会発表

所属学会

（最終更新日：2022-07-26 16:26:29）

  マスダ　キヨシ   Kiyoshi Masuda
  増田　清士
   所属   川崎医科大学医学部

職種学長付特任教授

■ 現在の専門分野

分子生物学, 消化器内科学　（キーワード：転写後調節機構、RNA結合蛋白質、遺伝子発現調節、ゲノム医学）

■ 学術雑誌

1.	2022/07/08	総説	circRNA: A New Biomarker and Therapeutic Target for Esophageal Cancer
2.	2021/06/29	原著	Significance of Circular FAT1 as a Prognostic Factor and Tumor Suppressor for Esophageal Squamous Cell Carcinoma
3.	2021/05/05	原著	Functionally confirmed compound heterozygous ADAM17 missense loss-of-function variants cause neonatal inflammatory skin and bowel disease 1
4.	2019/10/25	原著	Claudin-6 is a single prognostic marker and functions as a tumor-promoting gene in a subgroup of intestinal type gastric cancer.
5.	2019/08	原著	Prognostic significance of GAD1 overexpression in patients with resected lung adenocarcinoma
6.	2019/05	総説	Diverse roles of RNA-binding proteins in cancer traits and their implications in gastrointestinal cancers
7.	2019/04	原著	Toll-Like Receptor 9 Plays a Pivotal Role in Angiotensin II-Induced Atherosclerosis
8.	2019/01	原著	Novel compound heterozygous CDH23 variants in a patient with Usher syndrome type I
9.	2019/01	総説	RNA結合蛋白質の機能調節を目指した食道癌治療戦略
10.	2018/10	総説	RNA結合蛋白質の機能調節を目指した食道癌治療戦略
11.	2018/04	原著	Primary microcephaly caused by novel compound heterozygous mutations in ASPM
12.	2018/03	原著	A rare male patient with classic Rett syndrome caused by MeCP2_e1 mutation
13.	2018/02	原著	Manifestation of recessive combined D-2-, L-2-hydroxyglutaric aciduria in combination with 22q11.2 deletion syndrome
14.	2017/11	原著	Prevalence of pathogenic germline variants detected by multigene sequencing in unselected Japanese patients with ovarian cancer
15.	2017/09	原著	Frequent silencing of RASSF1A by DNA methylation in thymic neuroendocrine tumours
16.	2017/09	原著	KH-type splicing regulatory protein is involved in esophageal squamous cell carcinoma progression
17.	2017/08	原著	Construction of a combinatorial pipeline using two somatic variant calling methods for whole exome sequence data of gastric cancer
18.	2017/08	原著	Novel CLCN7 compound heterozygous mutations in intermediate autosomal recessive osteopetrosis
19.	2017/08	原著	The first Japanese patient with mandibular hypoplasia, deafness, progeroid features and lipodystrophy diagnosed via POLD1 mutation detection
20.	2017/06	総説	RNA Binding Proteins and Genome Integrity
21.	2017/04	原著	A 590 kb deletion caused by non-allelic homologous recombination between two LINE-1 elements in a patient with mesomelia-synostosis syndrome
22.	2017/04	原著	A case with concurrent duplication, triplication, and uniparental isodisomy at 1q42.12-qter supporting microhomology-mediated break-induced replication model for replicative rearrangements
23.	2017/04	原著	Clinical utility of circulating cell-free Epstein-Barr virus DNA in patients with gastric cancer
24.	2017/03	原著	Adverse parenting is associated with blunted salivary cortisol awakening response and altered expression of glucocorticoid receptor beta and beta2-adrenergic receptor mRNAs in leukocytes in Japanese medical students
25.	2017/01	原著	Frequent silencing of the candidate tumor suppressor TRIM58 by promoter methylation in early-stage lung adenocarcinoma
26.	2017/01	原著	Genome-first approach diagnosed Cabezas syndrome via novel CUL4B mutation detection
27.	2017/01	原著	Monitoring the HER2 copy number status in circulating tumor DNA by droplet digital PCR in patients with gastric cancer
28.	2016/12	原著	Novel human mutation and CRISPR/Cas genome-edited mice reveal the importance of C-terminal domain of MSX1 in tooth and palate development
29.	2016/11	原著	Exome-first approach identified a novel gloss deletion associated with Lowe syndrome
30.	2016/09	原著	A novel missense mutation of COL5A2 in a patient with Ehlers-Danlos syndrome
31.	2016/09	総説	Homeodomain-Interacting Protein Kinase-2: A Critical Regulator of the DNA Damage Response and the Epigenome
32.	2016/08	原著	Serine/arginine-rich splicing factor 7 regulates p21-dependent growth arrest in colon cancer cells
33.	2016/06	原著	Detection of 1p36 deletion by clinical exome-first diagnostic approach
34.	2016/04	原著	A novel COL11A1 missense mutation in siblings with non-ocular Stickler syndrome
35.	2016/04	原著	A novel frameshift mutation of CHD7 in a Japanese patient with CHARGE syndrome
36.	2016/04	原著	Ultraconserved region-containing Transformer 2beta4 controls senescence of colon cancer cells
37.	2016/03	原著	Tumor-promoting function and prognostic significance of the RNA-binding protein T-cell intracellular antigen-1 in esophageal squamous cell carcinoma
38.	2015/12	原著	A unique TBX5 microdeletion with microinsertion detected in patient with Holt-Oram syndrome
39.	2015/11	原著	A novel COL11A1 mutation affecting splicing in a patient with Stickler syndrome
40.	2015/11	原著	Ectopic Aire Expression in the Thymic Cortex Reveals Inherent Properties of Aire as a Tolerogenic Factor within the Medulla
41.	2015/11	原著	Simultaneous Detection of Both Single Nucleotide Variations and Copy Number Alterations by Next-Generation Sequencing in Gorlin Syndrome
42.	2015/10	原著	HER2 amplification detected in the circulating DNA of patients with gastric cancer: a retrospective pilot study
43.	2015/06	原著	Deep intronic GPR143 mutation in a Japanese family with ocular albinism
44.	2015/06	原著	Homeodomain-interacting protein kinase 2 regulates DNA damage response through interacting with heterochromatin protein 1gamma
45.	2015/05	原著	Transformer 2beta and miR-204 regulate apoptosis through competitive binding to 3' UTR of BCL2 mRNA
46.	2014/08	原著	HuR regulates alternative splicing of the TRA2beta gene in human colon cancer cells under oxidative stress
47.	2014/03	原著	Downregulation of serine/arginine-rich splicing factor 3 induces G1 cell cycle arrest and apoptosis in colon cancer cells
48.	2014/03	原著	Novel PAX9 mutations cause non-syndromic tooth agenesis
49.	2014/02	原著	Oxidative stress-inducible truncated serine/arginine-rich splicing factor 3 regulates interleukin-8 production in human colon cancer cells
50.	2013/11	原著	Ets1 and heat shock factor 1 regulate transcription of the Transformer 2beta gene in human colon cancer cells
51.	2013/11	原著	Truncated serine/arginine-rich splicing factor 3 accelerates cell growth through up-regulating c-Jun expression
52.	2013/10	原著	Chronic academic stress increases a group of microRNAs in peripheral blood
53.	2013/08	総説	Application of DNA microarray technology to gerontological studies
54.	2013/08	総説	NF90 in posttranscriptional gene regulation and microRNA biogenesis
55.	2013/05	原著	Chronic inhibition of tumor cell-derived VEGF enhances the malignant phenotype of colorectal cancer cells
56.	2012/10	原著	Heterogeneous nuclear ribonucleoprotein C1/C2 controls the metastatic potential of glioblastoma by regulating PDCD4
57.	2012/09	総説	General RBP expression in human tissues as a function of age
58.	2012/08	原著	Role of miR-19b and its target mRNAs in 5-fluorouracil resistance in colon cancer cells
59.	2012/05	原著	MicroRNAs miR-144/144* and miR-16 in peripheral blood are potential biomarkers for naturalistic stress in healthy Japanese medical students
60.	2011/08	原著	Skipping of an alternative intron in the srsf1 3' untranslated region increases transcript stability
61.	2011/07	原著	Circulating vascular endothelial growth factor is independently and negatively associated with trait anxiety and depressive mood in healthy Japanese university students
62.	2011/07	原著	Effects of chronic academic stress on mental state and expression of glucocorticoid receptor alpha and beta isoforms in healthy Japanese medical students
63.	2011/03	原著	Global dissociation of HuR-mRNA complexes promotes cell survival after ionizing radiation
64.	2010/09	原著	miR-375 inhibits differentiation of neurites by lowering HuD levels
65.	2010/08	原著	High-throughput screening of brief naturalistic stress-responsive cytokines in university students taking examinations
66.	2009/10	原著	Increased MKK4 abundance with replicative senescence is linked to the joint reduction of multiple microRNAs
67.	2009/09	総説	RNA-binding proteins implicated in the hypoxic response
68.	2009/08	原著	Interleukin 10 inhibits interferon gamma- and tumor necrosis factor alpha-stimulated activation of NADPH oxidase 1 in human colonic epithelial cells and the mouse colon
69.	2009/08	原著	Oxidative stress-induced alternative splicing of transformer 2beta (SFRS10) and CD44 pre-mRNAs in gastric epithelial cells
70.	2009/07	原著	Receptor activator of nuclear factor-kappaB ligand-induced mouse osteoclast differentiation is associated with switching between NADPH oxidase homologues
71.	2009/07	原著	Tissue- and age-dependent expression of RNA-binding proteins that influence mRNA turnover and translation
72.	2009/06	原著	Interleukin-18 is a crucial determinant of vulnerability of the mouse rectum to psychosocial stress
73.	2009/02	原著	NADPH oxidase-derived reactive oxygen species are essential for differentiation of a mouse macrophage cell line (RAW264.7) into osteoclasts
74.	2008/12	原著	Tumor necrosis factor alpha activates transcription of the NADPH oxidase organizer 1 (NOXO1) gene and upregulates superoxide production in colon epithelial cells
75.	2008/05	原著	A novel tumor-promoting function residing in the 5' non-coding region of vascular endothelial growth factor mRNA
76.	2007/10	原著	Gene expression signature in peripheral blood cells from medical students exposed to chronic psychological stress
77.	2007/09	原著	Physical exercise-associated gene expression signatures in peripheral blood
78.	2006/02	原著	Interferon-gamma activates transcription of NADPH oxidase 1 gene and upregulates production of superoxide anion by human large intestinal epithelial cells
79.	2005/12	原著	Microarray analysis of stress-related gene expression in patients with Meniere's disease
80.	2005/08	総説	Gene expression profiling in peripheral blood leukocytes as a new approach for assessment of human stress response
81.	2004/02	原著	当院における手術不能膵癌に対するGemcitabine使用成績
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■ 学会発表

1.	2021/09/10	公共データを用いた新規胃がん予後マーカー・治療標的の探索とその機能解析（口頭，シンポジウム・ワークショップパネル（公募））
2.	2019/08/22	学修成果の評価と学修行動比較調査の可視化について（口頭，一般）
3.	2019/05/13	KHSRP involved in esophageal squamous cell carcinoma progression by inducing the expression of a set of oncogenic miRNAs （ポスター掲示，一般）
4.	2018/09/29	In silico解析による新規治療標的候補遺伝子OEGC1の同定と機能解析（口頭，一般）
5.	2018/09/28	KHSRPは癌促進型miRNA発現を誘導し食道癌の進展を促進する（口頭，一般）
6.	2018/09/27	肺腺癌の予後を予測可能な遺伝子群の探索（ポスター掲示，一般）
7.	2017/12/06	RNA結合蛋白質TIA1の機能調節に着目した新規食道癌治療法の開発（ポスター掲示，一般）
8.	2017/09/28	Functional modification of TIA1 could be a potential therapeutic target for esophageal squamous cell carcinoma （口頭，一般）
9.	2017/02/05	Tumor-promoting function and prognostic significance of the RNA-binding protein T-cell intracellular antigen-1 in esophageal squamous cell carcinoma （ポスター掲示，一般）
10.	2016/11/30	食道扁平上皮癌におけるRNA結合蛋白質TIA1を介した新規癌進展機構の解明（ポスター掲示，一般）
11.	2016/11/03	MRF1は癌関連miRNA発現異常を誘導し食道癌の進展を促進する（口頭，シンポジウム・ワークショップパネル（公募））
12.	2015/12/01	RNA binding protein, SSP, induces cell viability of squamous cell carcinoma by posttranscriptional regulation （ポスター掲示，一般）
13.	2015/11/08	A novel RNA binding protein, MRF1, induces cell growth in squamous cell carcinoma modulating microRNA expression （ポスター掲示，一般）
14.	2015/10/08	A novel RNA binding protein, MRF1, induces cell growth in squamous cell carcinoma modulating cancer-associated microRNA expression （ポスター掲示，一般）
15.	2014/12/06	転写後調節異常による老化関連疾患の発症機構の解明（口頭，一般）
16.	2014/11/25	A novel RNA binding protein, SSP-1, induced cell growth in squamous cell carcinoma modulating cancer-associated gene expression in posttranscriptional mechanism （ポスター掲示，一般）
17.	2014/10/19	An RNA binding protein, SSP1, induced cell growth in squamous cell carcinoma through posttranscriptional regulation （ポスター掲示，一般）
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■ 所属学会

1.		日本癌学会
2.		日本消化器内視鏡学会
3.		日本消化器病学会
4.		∟ 中国支部評議員
5.		日本内科学会
6.		日本分子生物学会
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