(Last updated : 2024-04-30 14:33:40)
  Kazuhito Tsuboi
   Department   Kawasaki Medical School  Kawasaki Medical School, Department of Pharmacology,
   Position   Associate Professor
■ Present specialized field
Pharmacology, Medical biochemistry, Pharmaceutical hygiene and biochemistry, Applied biochemistry , Pharmaceutical chemistry and drug development sciences (Key Word:Lipid Biological Chemistry) 
■ BooK
1. 2022/09/25   Assay of NAAA activity., Methods Mol. Biol., Vol. 2576, Endocannabinoid Signaling: Methods and Protocols 2nd Edition. 
2. 2022/04/01   Involvement of the γ isoform of cPLA2 in the biosynthesis of bioactive N-acylethanolamines., A Themed Issue in Honor of Professor Raphael Mechoulam: The Father of Cannabinoid and Endocannabinoid Research 
3. 2020/11/16   Inhibition of NAPE-PLD activity by natural compounds and synthetic drugs, and its biological relevance., Drug Discovery Series No. 76. New tools to interrogate endocannabinoid signalling–from natural compounds to synthetic drugs. 
4. 2016/03/11   Assay of NAAA activity., Methods Mol. Biol., Vol. 1412, Endocannabinoid Signaling: Methods and Protocols. 
5. 2014/09   Metabolic enzymes for endocannabinoids and endocannabinoid-like mediators., The Endocannabinoidome: The World of Endocannabinoids and Related Mediators. 
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■ Journal
1. 2024/02/17 A fluorogenic substrate for the detection of lipid amidases in intact cells. 
2. 2023/06/20 Genetic ablation of Saposin-D in Krabbe disease eliminates psychosine accumulation but does not significantly improve demyelination 
3. 2023/05/16 GDE7 produces cyclic phosphatidic acid in the ER lumen functioning as a lysophospholipid mediator. 
4. 2022/12/25 A simple enzyme assay for glycerophosphodiesterase GDE4 and GDE7 using fluorescent substrate 
5. 2021/10/18 Development of a selective fluorescence-based enzyme assay for glycerophosphodiesterase family members GDE4 and GDE7. 
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■ Presentation
1. 2023/03/14 Mechanism of decreased expression of the lipid mediator-degrading enzyme in fibrotic lung (Poster notice,General) 
2. 2022/11/24 Pathophysiological analysis of Saposin D-deficient Twitcher mice (Speech,General) 
3. 2022/11/11 Glycerophosphodiesterase 7 produces cyclic phosphatidic acid in the ER lumen (Poster notice,General) 
4. 2022/11/11 Role of senescent alveolar epithelial cells in pulmonary fibrosis (Poster notice,General) 
5. 2022/09/09 A novel fluorogenic probe to monitor the activity of acid ceramidase, fatty acid amide hydrolase and N-acylethanolamine acid amidase. (Poster notice,General) 
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