Faculty Information - 林　宏明

（Last updated : 2022-04-25 12:24:29）

林　宏明
Department Kawasaki Medical School Kawasaki Medical School, Department of Dermatology,

Position

■ BooK

1.	2016	Silica-induced immunotoxicity: chronic and aberrant activation of immune cells, In: Allergy and Immunotoxicology in Occuaptional Health, (Series Title: Current Topics in Environmental Health and Preventive Medicine)
2.	2013	Asbestos-induced mesothelioma: Tumor escape and alteration of immune surveillance., Recent Research Developments in Immunology
3.	2013	Immunological effects of silica., Encyclopedia of Metalloproteins
4.	2011/09	Immunological effects of silica and related dysregulation of autoimmunity., Autoimmune Disorders-Pathogenetic Aspects
5.	2010/10	Dysregulation of Autoimmunity Caused by Silica Exposure: Fas-Mediated Apoptosis in T Lymphocytes Derived from Silicosis Patients., Autoimmune Disorders: Symptoms, Diagnosis and Treatment.

■ Journal

1.	2019/05	Infection of Helicobacter cinaedi Should be Treated for an Adequate Duration with Combined Antibiotic Therapy: Author's Reply.
2.	2019/03	Cross-sectional multicenter observational study of psoriatic arthritis in Japanese patients: Relationship between skin and joint symptoms and results of treatment with tumor necrosis factor-alpha inhibitors.
3.	2018/12	Bacteremia possibly caused by Helicobacter cinaedi and associated with painful erythema in rheumatoid arthritis with malignant lymphoma
4.	2018/07	Benign cephalic histiocytosis: A case with some infiltrate of CD1a positive langerin negative cells
5.	2017/04	Silicosis and autoimmunity
6.	2017	Accelerated cell-cycle progression of human regulatory T cell-like cell line caused by continuous exposure to asbestos fibers.
7.	2017	Alteration of immune cells in silicosis: Roles in development of autoimmunity and lung fibrosis.
8.	2017	Clinical evaluation of CENP-B and Scl-70 autoantibodies in silicosis patients.
9.	2015/10	Familial Mediterranean fever with onset in the 70s showing various neutrophilic dermatosis.
10.	2015/04	Development of aseptic subcutaneous abscess after tocilizumab therapy in a patient with SAPHO syndrome complicated by amyloid A amyloidosis
11.	2015	Enhancement of regulatory T cell-like suppressive function in MT-2 by long-term and low-dose exposure to asbestos.
12.	2014/09	Chronic exposure to asbestos enhances TGF-bata1 production in the human adult T cell leukemia virus-immortalized T cell line MT-2
13.	2014/09	Refractory eosinophilic pustular folliculitis resistant to oral indomethacin successfully treated with adjuvant topical indomethacin.
14.	2014/08	Silica exposure and altered regulation of autoimmunity
15.	2014/06	Functional properties of CD8+ lymphocytes in patients with pleural plaque and malignant mesothelioma
16.	2013/09	Alteration of cytoskeletal molecules in a human T cell line caused by continuous exposure to chrysotile asbestos.
17.	2013/08	Predominance of Th2 and regulatory cytokines in the serum of a patient with IgG4-related lymphadenopathy
18.	2013/07	Effect of asbestos exposure on differentiation of cytotoxic T lymphocytes in mixed lymphocyte reaction of human peripheral blood mononuclear cells.
19.	2013/06	Systemic Lupus Erythematosus Suspected of C4 Deficiency due to Sustained Low Levels of C4
20.	2013/04	A Case of Acute Generalized Exanthematous Pustulosis with Pranlukast or Cefditoren Pivoxil Suspected as the Causative Drug.
21.	2013/03	Present status of Rosacea and Rosecea-like dermatitis: Epidemiologic aspects of patients seen at Kawasaki Medical School Hospital from 2002 to 2011.
22.	2013	Exploration of biomarkers for asbestos exposure and occurrence of malignant mesothelioma based on the immunological effects of asbestos.
23.	2012/07	Environmental factors producing autoimmune dysregulation-Chronic activation of T cells caused by silica exposure.
24.	2012/07	Resistance to asbestos-induced apoptosis with continuous exposure to crocidolite on a human T cell
25.	2012/06	Successful treatment with infliximab for refractory pyoderma gangrenosum associated with inflammatory bowel disease.
26.	2012	Asbestos-Induced Cellular andMolecular Alteration of Immunocompetent Cells and Their Relationship with Chronic Inflammation and Carcinogenesis
27.	2012	Review of reduced tumor immunity caused by asbestos exposure to immunocompetent cells such as T and NK cells.
28.	2011/10	Decreased CXCR3 expression in CD4+ T cells exposed to asbestos or derived from asbestos-exposed patients.
29.	2011/09	Reduction of CXC chemokine receptor 3 in an in vitro model of continuous exposure to asbestos in a human T-cell line, MT-2.
30.	2011/06	Quick detection of overexpressed genes caused by myeloma-specific chromosomal translocations using multiplex RT-PCR.
31.	2011/01	Dysregulation of autoimmunity caused by silica exposure and alteration of Fas-mediated apoptosis in T lymphocytes derived from silicosis patients.
32.	2011/01	Suppressive effect of asbestos on cytotoxicity of human NK cells.
33.	2010/10	Dysregulation of the Immune System Caused by Silica and Asbestos.
34.	2010/10	Reductive alteration of the regulatory function of the CD4(+)CD25(+) T cell fraction in silicosis patients.
35.	2010	Peripheral regulatory T cell from silicosis patients is susceptible to CD95-mediated apoptosis.
36.	2009/12	Decrease in phosphorylation of ERK following decreased expression of NK-cell activating receptors in human NK cell line exposed to asbestos.
37.	2009/09	Impairment in cytotoxicity and expression of NK-cell activating receptors on human NK cells following exposure to asbestos fibers.
38.	2009/07	Cytokine alteration and speculated immunological pathophysiology in silicosis and asbestos-related diseases.
39.	2009/06	Two weeks of abidance in negatively-charged air conditions causes alteration of natural killer cell function.
40.	2009/03	Cyclophosphamide and aminiotic membrane transplantation in the management of ocular disease in a case of antiepiligrin cicatricial pemphigoid
41.	2009/03	Cyclophosphamide and aminiotic membrane transplantation in the management of ocular disease in a case of antiepiligrin cicatricial pemphigoid
42.	2009/03	The biological effects of negatively-charged indoor aire conditions.
43.	2009	Effects of vitamin D receptor gene polymorphism on low-resistance training using exercise machines: the 'power Rehabilitation' program.
44.	2007/08	Immunological effects of silica and asbestos.
45.	2007	Keynote lecture in the 13th Japanese Society of Immunotoxicology (JSIT 2006) --- Pathophysiological Development and Immunotoxicology: what we have found from the researches related to the silica and silicate such as asbestos---.
46.	2007	Pathophysiological Development and Immunotoxicology: what we have found from the researches related to the silica and silicate such as asbestos.
47.	2007	Pathophysiological Development and Immunotoxicology: what we have found from the researches related to the silica and silicate such as asbestos.
48.	2006/11	Decreased expression levels of CD22 and L-selectin on peripheral blood B lymphocytes from patients with bullous pemphigoid.
49.	2006/11	Decreased expression levels of CD22 and L-selectin on peripheral blood B lymphocytes from patients with bullous pemphigoid.
50.	2006/11	TRAIL expression up-regulated by interferon-gamma via phosphrylation of STAT1 induces myeloma cell death
51.	2006/10	Expression of the T cell receptor Vβ repertoire in a human T cell resistant to asbestos-induced apoptosis and peripheral blood T cells from patients with silica and asbestos-related diseases.
52.	2006/07	Involvement of IL-10 and Bcl-2 in resistance against an asbestos-induced apoptosis of T cells.
53.	2006	Asbestos-related carcinogenesis and immunological effects.
54.	2006	Asbestos-related carcinogenesis and immunological effects.
55.	2006	Role for interleukin-6 and insulin-like growth factor-I via PI3-K/Akt pathway in the proliferation of CD56- and CD56+ multiple myeloma cells.
56.	2006	Role for interleukin-6 and insulin-like growth factor-I via PI3-K/Akt pathway in the proliferation of CD56- and CD56+ multiple myeloma cells.
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■ Presentation

1.	2016/10/13	Cases of Japanese spotted fever and scrub typhus (Tsutsugamushi disease) experienced in our hospitals （Poster notice，General）
2.	2016/03/14	Effect Of IL-2 Addition on Granzyme B Expression and Proliferation in CD8+ Lymphocytes Exposed to Asbestos During MLR （Poster notice，General）
3.	2015/06	Effect of IL-2 addition on the suppressed induction of human CTL in mixed lymphocyte reactions upon exposure to asbestos （Poster notice）
4.	2015/06	Functional properties of CD8+ lymphocytes in asbestos-exposed patients with pleural plaque and malignant mesothelioma. （Speech）
5.	2014/10/31	Immune stimulation cansed by silica and dysregulation of autoimmunity （General）
6.	2014/03/27	The characteristics of activated lymphocytes in silicosis differing in Th17 phenotype from systemic sclerosis （Speech，General）
7.	2014/03/25	Analysis of blood DcR3 concentration andits correlation to clinical paramaters of autoimmune diseases in silicosis patients （Poster notice，General）
8.	2012/11/15	Thymoma- associated multi-organ autoimmunity: A graft-versus- host-like disease （Speech，General）
9.	2012/06/14	Cytokine expression analyses before and after plasmapheresis in two patients with SJS/TEN （Poster notice，General）
10.	2010/12/03	BP180 IgE antoantibodies as detected by ELISA in the course of treatment in patients with bullous pemphigoid （Speech，General）
11.	2010/09/02	Suppressive effects of asbestos-exposure on the differentiation of human cytotoxic T lymphocytes, accompanied with decrease in IFN-γ and TNF-α. （Poster notice，General）
12.	2010/04/08	Analysis of immune index in asbesots-related disease. （Poster notice，Panelist at Symposium/Workshop (Other)）
13.	2010/04/08	Differentiation into human cytotoxic T lymphocytes are suppressed under exposure to asbestos. （Poster notice，General）
14.	2010/04/08	Immunological effects of silica and asbestos. （Speech，Panelist at Symposium/Workshop (Other)）
15.	2010/04/08	Suppressive effect of asbestos on cytotoxicity of human NK cells. （Speech，Panelist at Symposium/Workshop (Other)）
16.	2008/05/14	Reduced function of the peripheral CD4+25+ fraction in silicosis patients exposed to environmental factors for SSc. （General）
17.	2008/05/14	Reduced function of the peripheral CD4+25+ fraction in silicosis patients exposed to environmental factors for SSc. （General）
18.	2007/11/15	Cyclophosphamide and amniotic membrane transplantation in the management of ocular disease in a case of anti-laminin5 mucous membrane pemphigoid. （General）
19.	2007/11/15	Cyclophosphamide and amniotic membrane transplantation in the management of ocular disease in a case of anti-laminin5 mucous membrane pemphigoid. （General）
20.	2007/05/18	Reduced function of the peripheral CD4+25+ fraction in silicosis patients exposed to environmental factors for SSc.
21.	2007/05/18	Reduced function of the peripheral CD4+25+ fraction in silicosis patients exposed to environmental factors for SSc.
22.	2007/01/20	免疫グロブリン静注後の汗疱状湿疹(dyshidrotic eczema after intravenous immunoglobulin therapy) （Speech，General）
23.	2007/01/20	免疫グロブリン静注後の汗疱状湿疹(dyshidrotic eczema after intravenous immunoglobulin therapy) （Speech，General）
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