Faculty Information - Soji Nishina

Present specialized field

BooK

Journal

Presentation

（Last updated : 2023-09-12 17:53:24）

Soji Nishina
Department Kawasaki Medical School Kawasaki Medical School, Department of Gastroenterology and Hepatology,

Position Professor

■ Present specialized field

Gastroenterology (Key Word：hepatitis,oxidative stress,hepatocarcinogenesis,mitochondria,iron metabolism)

■ BooK

2019

Liver Cirrhosis with Inherited Liver Disease: Hemochromatosis, The Evolving Landscape of Liver Cirrhosis Management

■ Journal

1.	2021/03/05	Long-term phlebotomy successfully alleviated hepatic iron accumulation Open Access in a ferroportin disease patient with a mutation in SLC40A1: a case report
2.	2021/03	Importance of HBsAg recognition by HLA molecules as revealed by responsiveness to different hepatitis B vaccines
3.	2020/10/24	Nanoparticle-mediated delivery of 2-deoxy-D-glucose induces antitumor immunity and cytotoxicity in liver tumors in mice.
4.	2020/09/25	Iron loss triggers mitophagy through induction of mitochondrial ferritin
5.	2019/01	Dipeptidyl Peptidase 4 Inhibitors Reduce Hepatocellular Carcinoma by Activating Lymphocyte Chemotaxis in Mice.
6.	2019	Mitochondrial damage and iron metabolic dysregulation in hepatitis C virus infection
7.	2018/06	Wisteria floribunda agglutinin-positive Mac-2 binding protein predicts the development of hepatocellular carcinoma in patients with non-alcoholic fatty liver disease.
8.	2018/06	Wisteria floribunda agglutinin-positive Mac-2 binding protein predicts the development of hepatocellular carcinoma in patients with non-alcoholic fatty liver disease.
9.	2016/05	Assessment of clinical and MRI features of de novo hypervascular HCC using gadoxetic acid-enhanced MRI
10.	2015/09	Fibroblast activation protein-alpha-expressing fibroblasts promote the progression of pancreatic ductal adenocarcinoma
11.	2015/04	Branched-chain amino acids reduce hepatic iron accumulation and oxidative stress in hepatitis C virus polyprotein-expressing mice
12.	2014/11	Hepatitis C Virus Core Protein Suppresses Mitophagy by Interacting with Parkin in the Context of Mitochondrial Depolarization
13.	2014/10	Hepatic oxidative stress in ovariectomized transgenic mice expressing the hepatitis C virus polyprotein is augmented through suppression of adenosine monophosphate-activated protein kinase/proliferator-activated receptor gamma co-activator 1 alpha signaling.
14.	2014/02	Mitochondrial reactive oxygen species as a mystery voice in hepatitis C.
15.	2013/12	Clinical usefulness of non-protein respiratory quotient measurement in non-alcoholic fatty liver disease.
16.	2013/12	Iron metabolic disorder in chronic hepatitis C: Mechanisms and relevance to hepatocarcinogenesis
17.	2013/07	Risk factors for survival and the development of hepatocellular carcinoma in patients with primary biliary cirrhosis
18.	2013/02	Clinical usefulness of non-protein respiratory quotient measurement in non-alcoholic fatty liver disease
19.	2012/07	Iron metabolic disorder in chronic hepatitis C:
20.	2011	A glycyrrhizin-containing preparation reduces hepatic steatosis inducedby hepatitis Cvirus protein and iron in mice
21.	2011	Type 1 interferon receptor in peripheral blood mononuclear cells may predict response to intra-arterial 5-fluorouracil + interferon therapy for advanced hepatocellular carcinoma
22.	2010/05	Hepatitis C virus protein and iron overload induce hepatic steatosis through the unfolded protein response in mice
23.	2008/06	Validating a Markov model of treatment for hepatitis C virus-related hepatocellular carcinoma.
24.	2008/01	Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription.
25.	2008	Mitochondrial electron transport inhibition in full genomic hepatitis C virus replicon cells is restored by reducing viral replication.
26.	2007	Stronger Neo-Minophagen C, a glycyrrhizin-containing preparation, protects liver against carbon tetrachloride-induced oxidative stress in transgenic mice expressing the hepatitis C virus polyprotein.
27.	2006	Hepatic iron overload induces hepatocellular carcinoma in transgenic mice expressing the hepatitis C virus polyprotein.
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■ Presentation

1.	2023/11/13	ANEAR-INFRARED-MODULATEDSYSTENENABLINGEFFICIENTDELIVERY OF GLUCOSE DERIVATIVE AS ANWE THERAPEUTIC STRATEGY FOR LIVER CANCER （Poster notice，General）
2.	2023/09/08	Alcohol is one of risk factors associated with the development of hepatocellular carcinoma in diabetes mellitus patients with non-viral chronic liver disease （Speech，Panelist at Symposium/Workshop (Applied)）
3.	2018/11/12	Mitochondria ferritin induces mitophagy under iron deficient condition （Poster notice，General）
4.	2018/05/13	Treatment of hepatocellular carcinoma using 2-deoxy-D-glucose encapsulated in PLGA nanoparticles iclesin mice （Speech，General）
5.	2017/10/23	Dipeptidyl peptidase 4 inhibitors reduce hepatocellular carcinoma by activating natural killer cell chemotaxis in mice （Poster notice，General）
6.	2017/10/21	Development of hepatocellular carcinoma after treatment with direct acting antivirals in hepatitis C virus-associated chronic liver diseases （Poster notice，General）
7.	2017/10/21	Loss of iron triggers mitophagy by inducing mitochondrial ferritin （Poster notice，General）
8.	2017/05/11	LOSS OF IRON UPREGULATES MITOCHONDRIA FERRITIN AND TRIGGERS MITOPHAGY THROUGH THE BINDING OF MITOCHONDRIA FERRITIN TO NUCLEAR RECEPTOR COACTIVATOR 4 （Speech，General）
9.	2016/11/13	Iron chelator suppresses hepatocarcinogenesis through mitophagy induction in STAM mice （Poster notice，General）
10.	2016/11/11	Dipeptidyl peptidase 4 (DPP4) inhibitor enhances natural killer cell chemotaxis, improving tumor immunity against hepatocellular carcinoma （Poster notice，General）
11.	2016/09/22	Comparison of therapeutic effect of sorafenib and drug eluting beads transcatheter arterial chemoembolization on hepatocellular carcinoma refractory to conventional transcatheter arterial chemoembolization （Poster notice，General）
12.	2016/02/22	DPP-4 inhibitor, anagliptin suppresses the progression of Hepatocellular carcinoma （Poster notice，General）
13.	2015/11/15	Iron chelation restores mitophagy suppressed by hepatitis C virus （Poster notice，General）
14.	2015/10/09	CD26 (DPP-4) as a molecular target for HCC treatment （Poster notice，General）
15.	2014/11/09	Oral glucose tolerance test predicts hepatic fibrosis in nonalcoholic fatty liver disease patients without overt diabetes mellitus. （Poster notice，General）
16.	2014/10/30	Hepatitis C virus core protein suppresses mitophagy by interacting with Parkin in the context of mitochondrial depolarization （Speech，General）
17.	2013/11	Hepatitis C virus core protein suppresses mitophagy by interacting with Parkin （Poster notice，General）
18.	2013/11	Ovariectomized transgenic mice expressing hepatitis C virus polyprotein develop hepatic steatosis through suppression of AMPK/PGC1a signaling （Poster notice，General）
19.	2013/11	Splenectomy causes hepatic inflammation and oxidative stress through activation of Kupffer cells in iron-overloaded mice （Poster notice，General）
20.	2013/09/24	Splenectomy causes hepatic inflammation and oxidative stress through activation of Kupffer cells in iron-overloaded mice （Poster notice，General）
21.	2013/05/05	The hepatitis C virus core protein suppresses mitophagy by affecting Parkin （Poster notice，General）
22.	2013/03/22	Suppressed Mitophagy in Transgenic Mice Expressing Hepatitis C Virus Polyprotein （Poster notice，General）
23.	2012/11/22	Hepatitis C virus core protein suppress mitophagy by interacting with Parkin （Poster notice，General）
24.	2012/11/10	Anti-interferon-alfa neutralizing antibodies interact with viral responses to interferon in with hepatitis C virus infection bearing interferon sensitive IL 28B single nucleotide polymorphisms （Poster notice，General）
25.	2012/11/10	Hepatitis C virus core protein suppresses mitophagy by interacting with Parkin （Poster notice，General）
26.	2012/11/10	Hepatitis C virus proteins suppress compensatory induction of reactive oxygen species-detoxifying enzymes following oxidative stress in the absence of estrogen （Poster notice，General）
27.	2012/11/10	Supplementation with branched-chain amino acids improved HCV-induced iron metabolic disorder via upregulation of antioxidant potential by restoring mitochondrial complex I function in iron overloaded transgenic mice expressing HCV polyprotein （Poster notice，General）
28.	2012/10/06	Hepatitis C virus core protein suppresses mitophagy by affecting Parkin （Poster notice，General）
29.	2011/11/04	Dietary supplementation with branched-chain amino acids reduces hepatic iron accumulation in iron overloaded transgenic mice expressing hepatitis C virus polyprotein （Poster notice，General）
30.	2011/11/04	Oral branched-chain amino acid supplementation reduces oxidative stress and interacts with iron metabolism in patients with hepatitis C virus-related advanced liver fibrosis A Pilot Study （Poster notice，General）
31.	2011/11/04	Risk factors for development of hepatocellular carcinoma in patients with primary biliary cirrhosis （Poster notice，General）
32.	2010/12/18	HCV-Induced Oxidative Stress and Metabolic Disorder （Poster notice，General）
33.	2010/12/17	GLYCYRRHIZIN REDUCES HEPATIC STEATOSIS INDUCED　BY HEPATITIS C VIRUS PROTEIN AND IRON OVERLOAD　IN MICE （Poster notice，General）
34.	2010/12/17	Hepatic steatosis induced by hepatitis C virus and iron, and its attenuation by glycyrrhizn （Poster notice，General）
35.	2010/10/30	Glycyrrhizin Reduces Hepatic Steatosis Induced by Hepatitis C Virus Protein and Iron Overload in Mice （Poster notice，General）
36.	2010/09/11	Different sensitivity to iron- induced oxidative stress between male and female transgenic mice expressing the hepatitis C virus polyprotein （Poster notice，General）
37.	2010/09/11	Hepatitis C virus protein and iron overload induce hepatic steatosis through the unfolded protein response in mice （Poster notice，General）
38.	2009/11/04	Clinically Aggressive Solid Pseudopapillary Tumor : A Case Report （Poster notice，General）
39.	2009/10/30	Inhibition of the Oxidative Stress Reduces Hepatic Iron Overloaded Through the Up-Regulation of Hepcidin Level in Transgenic Mice Expressing the Hepatitis C Virus Polyprotein （Poster notice，General）
40.	2008/11/02	Iron overload causes hepatic steatosis through the endoplasmic reticulum stress in transgenic mice expressing the hepatitis C virus polyprotein （Poster notice，General）
41.	2008/11/02	Mitochondrial electron transport inhibition in full genomic hepatitis C virus replicon cells is restored by reducing viral replication （Poster notice，General）
42.	2008/11/01	Analysis of gene expression related to the lipid and glucose metabolism in iron-overloded transgenic mice expressing the hepatitis C virus polyprotein （Poster notice，General）
43.	2007/11	Cosupplementation with vitamin E and coenzyme Q(10) reduces iron-overloaded induced hepatic steatosis in transgenic mice expressing the hepatitis C virus polyprotein. （Poster notice，General）
44.	2007/11	Hepatitis C virus-induced reactive oxygen species cause hepatic iron accumulation in mice by reducing hepcidin transcription. （Poster notice，General）
45.	2007/09	Hepatitis C virus-induced reactive oxygen species cause hepatic iron accumulation by reducing hepcidin transcription. （Speech，Panelist at Symposium/Workshop (Other)）
46.	2007/03/27	Lower hepcidin expression causes hepatic iron overload in transgenic mice expressing HCV polyptotein. （Speech，Panelist at Symposium/Workshop (Other)）
47.	2007/03/27	Replication of a Full-Length Hepatitis C Virus Genome Inhibits Mitochondrial Complex I Activity and Increases Mitochondrial ROS Production in Cell Culture System （Poster notice，General）
48.	2006/10/27	Decrease in hepcidin is essential for hepatic iron overload in transgenic mice expressing the hepatitis C virus polyprotein. （Poster notice，General）
49.	2006/10/27	Replication of a full-length hepatitis C virus genome inhibits mitochondrial complex I activity and increases mitochondrial ROS production in cell culture system. （Poster notice，General）
50.	2006/09/08	Iron overload and hepatocarcinogenesis in transgenic mice expressing the hepatitis C virus polyptotein. （Speech，Panelist at Symposium/Workshop (Other)）
51.	2005/11/11	Iron loading cause mitochondria injury and liver cancer in transgenic mice expressing the hepatitis C virus polyprotein. （Poster notice，General）
52.	2005/11/11	Iron overload develops in the absence of hepatic inflammation in transgenic mice expressing the hepatitis C virus polyprotein （Poster notice，General）
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