Faculty Information - Yasuhiro Takenouchi

■ Present specialized field

Pharmacology, Nutrition science and health science, Respiratory medicine

■ Journal

1.	2023/05/16	GDE7 produces cyclic phosphatidic acid in the ER lumen functioning as a lysophospholipid mediator.
2.	2022/04/18	Effects of dietary palmitoleic acid on vascular function in aorta of diabetic mice
3.	2021/10/18	Development of a selective fluorescence-based enzyme assay for glycerophosphodiesterase family members GDE4 and GDE7.
4.	2021/09/28	Sphingosine 1-phosphate receptor type 2 positively regulates interleukin (IL)-4/IL-13-induced STAT6 phosphorylation.
5.	2021/09/20	ATF4-mediated transcriptional regulation protects against β-cell loss during endoplasmic reticulum stress in a mouse model.
6.	2021/05/24	Involvement of acid ceramidase in the degradation of bioactive N-acylethanolamines.
7.	2020/06	Growth differentiation factor 15 facilitates lung fibrosis by activating macrophages and fibroblasts.
8.	2020	Effects of fish oil ingestion on haemorheological examinations in the low oxygen training
9.	2019/09	Chronic treatment with alpha-lipoic acid improves endothelium-dependent vasorelaxation of aortas in high-fat diet-fed mice.
10.	2018/05	Eicosapentaenoic acid ethyl ester improves endothelial dysfunction in type 2 diabetic mice.
11.	2014	Two types of overcontraction are involved in intrarenal artery dysfunction in type II diabetic mouse.
12.	2011	Angiotensin II causes endothelial dysfunction via the GRK2/Akt/eNOS pathway in aortas from a murine type 2 diabetic model.
13.	2010	Gender differences in vascular reactivity of aortas from streptozotocin-induced diabetic mice.
14.	2010	Relationship among superoxide-related enzyme, PPARs, and endothelium-dependent relaxation in murine aorta previously organ-culture in high-glucose condetions.
15.	2009	Gender differences in age-related endothelial function in murine aorta.
16.	2009	Gender differences in endothelial function in aortas from type 2 diabetic model mice.
17.	2008	Possible involvement of Akt activity in endothelial dysfunction in type 2 diabetic mice.
18.	2007	Insulin - induced impairment via peroxynitrite production of endothelium-dependent relaxation and sarco/endoplasmic reticulum Ca2+ - ATPase function in aoras from diabetic rats.
19.	2004	Impairment of PI3-K/Akt pathway underlies attenuated endothelial function in aorta of type 2 diabetic mouse model.
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■ Presentation

1.	2023/03/14	Mechanism of decreased expression of the lipid mediator-degrading enzyme in fibrotic lung （Poster notice，General）
2.	2022/11/11	Glycerophosphodiesterase 7 produces cyclic phosphatidic acid in the ER lumen （Poster notice，General）
3.	2022/11/11	Role of senescent alveolar epithelial cells in pulmonary fibrosis （Poster notice，General）
4.	2022/06/26	Acid ceramidase as a third N-acylethanolamine hydrolase in cells and tissues （Poster notice，General）
5.	2022/03/28	Hydrolysis of anti-inflammatory and anorexic N-acylethanolamines by acid ceramidase as revealed by using saposin D-deficient mice （Poster notice，General）
6.	2022/03/08	Development of a simple assay to measure glycerophosphodiesterase GDE4 and GDE7 activities for screening their Inhibitors （Poster notice，General）
7.	2022/03/08	Hydrolytic activity of acid ceramidase on N-acylethanolamines, anti-inflammatory and anorexic lipid mediators: an analysis using saposin D-knockout mice （Poster notice，General）
8.	2022/03/08	The crosstalk between Il-4/IL-13 and S1P/S1P₂ signaling in phorbol ester-treated THP-1 MΦs （Poster notice，General）
9.	2022/03/07	Analysis of the role of macrophage senescence in lung fibrosis using macrophage-specific p16 knockout mice （Poster notice，General）
10.	2021/11/03	Analysis of N-acylethanolamine-hydrolyzing activity using saposin D-deficient mice （Poster notice，General）
11.	2021/11/03	Fluorescence-based enzyme activity assay for glycerophosphodiesterase GDE4 and GDE7 （Poster notice，General）
12.	2021/11/03	S1P₂-Rho kinase pathway is necessary for full activation of STAT6 by IL-4/IL-13 in THP-1 macrophages （Poster notice，General）
13.	2021/11/03	The effect of p16 overexpression on gene expression of fibrosis-related factors in alveolar epithelial cells and macrophages （Poster notice，General）
14.	2021/04/27	Growth differentiation factor 15 activates macrophages and fibroblasts （Poster notice，General）
15.	2021/04/27	Role of acid ceramidase in the hydrolysis of anti-inflammatory and anorexic N-acylethanolamines （Poster notice，General）
16.	2021/04/27	The role of sphingosine 1-phosphate type 2 receptor on IL-4/IL-13-stimulated STAT6 phosphorylation in phorbol12-myristate13-acetate-treated THP-1 cells （Poster notice，General）
17.	2021/03/29	Changes in expression of fibrosis-related factors in p16 forced-expression cells （Poster notice，General）
18.	2021/03/09	Transcription factor ATF4 maintains pancreatic β-cell identity during ER stress （Speech，General）
19.	2021/03/08	Changes in expression of fibrosis-related factors in alveolar epithelial cells and macrophages by forced expression of p16 （Poster notice，General）
20.	2021/03/08	The role of sphingosine 1-phosphate receptor 2 on interleukin (IL)-4/IL-13-induced STAT6 phosphorylation in phorbol 12-myristate 13-acetate-stimulated THP-1 cells （Poster notice，General）
21.	2020/03/17	Altered gene expression of lysophosphatidic acid receptor subtypes in ischemia/reperfusion-induced renal interstitial fibrosis in mice. （General）
22.	2019/06/19	Expression of lysophosphatidic acid receptor subtypes in ischemia/reperfusion-induced renal fibrosis in mice. （Poster notice，General）
23.	2019/03/23	The effect of growth/differentiation factor 15 (GDF15) on lung fibrosis. （Poster notice，General）
24.	2019/03/16	The role of growth/differentiation factor 15 (GDF15) in lung fibrosis. （Poster notice，General）
25.	2018/07/05	Microarray analysis in bleomycin-induced lung fibrosis. （Poster notice，General）
26.	2018/07/04	Biosynthesis of N-acylethanolamine and lysophosphatidic acid by glycerophosphodiesterase GDE4 and GDE7. （Poster notice，General）
27.	2018/07/02	Gender difference of vascular functional changes in diabetic condition. （Poster notice，General）
28.	2011/06	Fenugreek with Reduced Bitterness Prevent Diet-induced Metabolic Disorders in Rats （Poster notice，General）
29.	2011/06	Inverse Effects of Fish Oil and Thiazolodonedione Administration on Insulin Sensitivity under Lipoatrophy Induced by Restricted Food Intake （Poster notice，General）
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■ Belonging society

1.	2005/04～	The Japanese Pharmacological Society
2.	2016/01～	The Pharmaceutical Society of Japan
3.	2017/06～	The Japanese Vascular Biology and Medicine Organaization