Akira Yamauchi    Department   Kawasaki Medical School  Kawasaki Medical School, Department of Biochemistry,    Position   Professor
Language	English
Title	Discovery of Pyrazole-based Anti-cancer Compounds via Cell-based Drug Discovery
Conference	The 82nd Annual Meeting of Japan Cancer Association
Promoters	Japan Cancer Association
Conference Type	Nationwide Conferences
Presentation Type	Poster notice
Lecture Type	General
Publisher and common publisher	Yamauchi A, Okamoto S, Choshi T, Katase N, Tomonobu N, Kinoshita R, Sakaguchi M, Yamamura M.
Date	2023/09/23
Country	Japan
Venue (city and name of the country)	横浜
Holding period	2023/09/21～2023/09/23
Summary	The development of new drugs for cancer therapy is a crucial topic for improving the lives of cancer patients. Wepreviously discovered a new compound 14-100 which showed an inhibition of pancreatic cancer cell dynamics despiteminimal cytotoxicity, using a Cell-based Drug Discovery approach. This compound inhibited the growth of pancreaticcancer as well as metastasis in vivo using a mouse orthotopic xenograft model. Compound 14-100 is a pyrazole-basedcompound. Recently, we synthesized analogues of Compound 14-100 and evaluated the eff ect on pancreatic cancer celldynamics. We found that at least 18 compounds inhibited cell dynamics (Biomedicine & Pharmacotherapy 155 (2022)113733). Compound 14-100 and its analogues, discovered through a Cell-based Drug Discovery approach, have shownpromising activity against pancreatic cancer, and may represent a new class of drug candidates for this disease.
URL for researchmap	https://www.c-linkage.co.jp/jca2023/index.html