Akira Yamauchi    Department   Kawasaki Medical School  Kawasaki Medical School, Department of Biochemistry,    Position   Professor
Language	Japanese
Title	A chemotaxis inhibitory agent selected using “TAXIScan” suppresses pancreatic cancer proliferation and metastasis.
Conference	The 81st Annual Meeting of the Japanese Cancer Association
Promoters	The Japanese Cancer Association
Conference Type	Nationwide Conferences
Presentation Type	Speech
Lecture Type	General
Publisher and common publisher	Akira Yamauchi, Masahiro Yamamura, Naoki Katase, Nahoko Tomonobu, Rie Kinoshita, Masakiyo Sakaguchi, Shuichiro Okamoto
Date	2022/09/29
Venue (city and name of the country)	Yokohama, Japan
Summary	Pancreatic cancer is one of the worst prognostic cancers and is highly metastatic and progressive. To conquer this malignant tumor, we utilized the cell dynamics assay device established previously to perform screening to find novel compounds regulating the migration of human pancreatic BxPC-3 cells. One of the hit compounds, Compound 14-100, showed the anti-tumor effect in vivo such as inhibiting metastasis based on the observation of fluorescent labeled tumor implants through the skin. Unexpectedly, the compound showed the inhibitory effect on the tumor proliferation despite with less cytotoxicity. Single cell RNA-seq revealed the change of gene expressions with regard to metastasis, angiogenesis, inflammation, and epithelial mesenchymal transition. These data suggest that compound 14-100 is effective to treat pancreatic cancer, which embodies "Cell-based Drug Discovery" especially focusing on cell dynamics.