スギヤマ　ヒトシ   杉山　斉    所属   川崎医療短期大学  教育部 医療介護福祉学科    職種   教授
言語種別	英語
発表タイトル	Histidyl-glutamine is associated with kidney volume in patients with autosomal dominant polycystic kidney disease.
会議名	World Congress of Nephrology 2026
学会区分	国際学会及び海外の学会
発表形式	ポスター掲示
講演区分	一般
発表者・共同発表者	Keiko Tanaka, Hitoshi Sugiyama, Hiroshi Morinaga, Haruhito A. Uchida, Jun Wada
発表年月日	2026/03/28
開催地 （都市, 国名）	Yokohama
概要	[Objective] To identify disease-specific metabolites, comprehensive metabolomic analysis of patient serum was performed. [Methods] Serum samples were obtained from 6 healthy controls, 28 patients with IgA nephropathy (IgAN), 28 with autosomal dominant polycystic kidney disease (ADPKD), and 28 with ANCA-associated vasculitis (AAV). Samples were analyzed using capillary electrophoresis time-of-flight mass spectrometry (CE-TOFMS). Correlations with disease-specific metabolites and clinical parameters (age, sex, renal function, proteinuria, etc.) were assessed using Spearman’s analysis, and their predictive ability was further evaluated by multiple regression. [Results] A total of 640 peaks were detected, of which 271 were assigned candidate compound names from the HMT metabolite library. Heatmap analysis confirmed distinct metabolic profiles across the four groups. Forty metabolites critical for group separation were identified; among these, four in IgAN, eight in ADPKD, and eight in AAV were classified as disease-specific. Correlation analysis between these disease-specific metabolites and clinical indicators revealed that histidyl-glutamine (His-Gln) was significantly elevated in ADPKD and inversely correlated with kidney volume. This association remained significant in multivariate analysis adjusted for age, sex, and eGFR. [Conclusion] Serum His-Gln levels were elevated in ADPKD and decreased with increasing kidney volume. His-Gln may serve as a biomarker of disease progression in ADPKD.